Conference Paper
Year 2022,
, 1 - 5, 16.09.2022
Abstract
References
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- Karaman, C. (2022). Engineering of N, P, S-Triple doped 3-dimensional graphene architecture: Catalyst-support for “surface-clean” Pd nanoparticles to boost the electrocatalysis of ethanol oxidation reaction. International Journal of Hydrogen Energy. https://doi.org/10.1016/j.ijhydene.2022.02.093
- Kulhari, S., Bharti, N., Bala, I., Arora, S., & Singh, G. (2016). Efficacy of pectoral nerve block versus thoracic paravertebral block for postoperative analgesia after radical mastectomy: a randomized controlled trial. BJA: British Journal of Anaesthesia, 117(3), 382-386.
- Mageswari, A., Srinivasan, R., Subramanian, P., Ramesh, N., & Gothandam, K. M. (2016). Nanomaterials: classification, biological synthesis and characterization. In Nanoscience in Food and Agriculture 3 (pp. 31-71). Springer.
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- Safdar, M., Ozaslan, M., Junejo, Y., & Channa, I. S. (2022). Cytotoxic and anticancer activity of a novel synthesized tet-AuNPs simultaneously activates p53 and inhibits NF-kB signaling in SKBR3 cell line. Toxicology and Environmental Health Sciences, 14(1), 69-76.
- Safdar, M., Ozaslan, M., Khailany, R. A., Latif, S., Junejo, Y., Saeed, M., . . . Kanabe, B. O. (2019). Synthesis, Characterization and Applications of a Novel Platinum-Based Nanoparticles: Catalytic, Antibacterial and Cytotoxic Studies. Journal of Inorganic and Organometallic Polymers and Materials. https://doi.org/10.1007/s10904-019-01387-7
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- Safdar, M., Qumar, G. M., Saravanan, M., Khailany, R. A., Ozaslan, M., Gondal, M. A., . . . Junejo, Y. J. J. o. C. S. (2019). Synthesis and characterization of Cefditoren capped silver nanoparticles and their antimicrobial and catalytic degradation of Ibuprofen. Journal of Cluster Science, 30(6), 1663-1671.
- Salem, A. K., Searson, P. C., & Leong, K. W. (2003). Multifunctional nanorods for gene delivery. Nature materials, 2(10), 668-671.
- Smith, D. M., Simon, J. K., & Baker, J. R., Jr. (2013). Applications of nanotechnology for immunology. Nat Rev Immunol, 13(8), 592-605. https://doi.org/10.1038/nri3488
- Sra, A. K., & Schaak, R. E. (2004). Synthesis of atomically ordered AuCu and AuCu3 nanocrystals from bimetallic nanoparticle precursors. Journal of the American Chemical Society, 126(21), 6667-6672.
- Surapaneni, S. K., Bashir, S., & Tikoo, K. (2018). Gold nanoparticles-induced cytotoxicity in triple negative breast cancer involves different epigenetic alterations depending upon the surface charge. Sci Rep, 8(1), 12295. https://doi.org/10.1038/s41598-018-30541-3
- Uzma, M., Sunayana, N., Raghavendra, V. B., Madhu, C. S., Shanmuganathan, R., & Brindhadevi, K. (2020). Biogenic synthesis of gold nanoparticles using Commiphora wightii and their cytotoxic effects on breast cancer cell line (MCF-7). Process Biochemistry, 92, 269-276.
- Wege, A. K., Schmidt, M., Ueberham, E., Ponnath, M., Ortmann, O., Brockhoff, G., & Lehmann, J. (2014). Co-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice: a novel approach to generate tumor cell specific human antibodies. MAbs, In MAbs (Vol. 6, No. 4, pp. 968-977). Taylor & Francis.
Synthesis and Characterization of Gold/Silver Bimetallic Nanoparticles Using Trastuzumab: An Enhanced Anti-Cancer Activity
Abstract
Bimetallic nanoparticles are getting a lot of attention in medicine and society because they might have interesting physical and synthetic properties, such as higher affinity, a lower molecular weight, and a larger surface area. Trastuzumab capped gold/silver bimetallic nanoparticles (Au/Ag-BNPs) were prepared for the purpose of enhancing the effects of Au/Ag-BNPs on SKBR3 breast cancer cells in order to reduce trastuzumab resistance. Au/Ag-BNPs were produced chemically. These Au/Ag-BNPs were characterized using various techniques. UV-Visible (UV-Vis) spectroscopy were used to monitor Plasmon absorption maxima at 462 nm. X-ray powder diffraction (XRD) pattern was utilized to confirm the crystalline nature of the BNPs. Lastly, Fourier transformed infrared (FT-IR) spectroscopy was used to investigate the bonding patterns of the NPs. In SKBR3 human breast cancer cells, the biological characteristics of these NPs were exemplary. Based on the results, we concluded that these gold/silver bimetallic nanoparticles have anticancer potential and can serve as an alternative to decrease the trastuzumab resistance of SKBR3 breast cancer cells. However, additional research is required to corroborate these results.
References
- Dziawer, Ł., Majkowska-Pilip, A., Gaweł, D., Godlewska, M., Pruszyński, M., Jastrzębski, J., . . . Bilewicz, A. (2019). Trastuzumab-modified gold nanoparticles labeled with 211At as a prospective tool for local treatment of HER2-positive breast cancer. Nanomaterials, 9(4), 632.
- Karaman, C. (2022). Engineering of N, P, S-Triple doped 3-dimensional graphene architecture: Catalyst-support for “surface-clean” Pd nanoparticles to boost the electrocatalysis of ethanol oxidation reaction. International Journal of Hydrogen Energy. https://doi.org/10.1016/j.ijhydene.2022.02.093
- Kulhari, S., Bharti, N., Bala, I., Arora, S., & Singh, G. (2016). Efficacy of pectoral nerve block versus thoracic paravertebral block for postoperative analgesia after radical mastectomy: a randomized controlled trial. BJA: British Journal of Anaesthesia, 117(3), 382-386.
- Mageswari, A., Srinivasan, R., Subramanian, P., Ramesh, N., & Gothandam, K. M. (2016). Nanomaterials: classification, biological synthesis and characterization. In Nanoscience in Food and Agriculture 3 (pp. 31-71). Springer.
- Maximiano, S., Magalhaes, P., Guerreiro, M. P., & Morgado, M. (2016). Trastuzumab in the treatment of breast cancer. BioDrugs, 30(2), 75-86.
- Mejia, S. P., Sánchez, A., Vásquez, V., & Orozco, J. J. F. i. p. (2021). Functional nanocarriers for delivering itraconazole against fungal intracellular infections. 12.
- Mi, Y., Liu, X., Zhao, J., Ding, J., & Feng, S.-S. (2012). Multimodality treatment of cancer with herceptin conjugated, thermomagnetic iron oxides and docetaxel loaded nanoparticles of biodegradable polymers. Biomaterials, 33(30), 7519-7529.
- Rebischung, C., Barnoud, R., Stéfani, L., Faucheron, J.-L., & Mousseau, M. (2005). The effectiveness of trastuzumab (Herceptin) combined with chemotherapy for gastric carcinoma with overexpression of the c-erbB-2 protein. Gastric Cancer, 8(4), 249-252.
- Safdar, M., & Ozaslan, M. (2022). Enhanced Catalytic, Antibacterial and Anti-cancer Activities of Erythromycin Capped Gold Nanoparticles. Journal of Inorganic and Organometallic Polymers and Materials, 1-9.
- Safdar, M., Ozaslan, M., & Junejo, Y. (2021). Synthesis, Characterization and Employed Doxycycline Capped Gold Nanoparticles on TRP Channel Expressions in SKBR3 Breast Cancer Cells and Antimicrobial Activity. Journal of Cluster Science, 1-8.
- Safdar, M., Ozaslan, M., Junejo, Y., & Channa, I. S. (2022). Cytotoxic and anticancer activity of a novel synthesized tet-AuNPs simultaneously activates p53 and inhibits NF-kB signaling in SKBR3 cell line. Toxicology and Environmental Health Sciences, 14(1), 69-76.
- Safdar, M., Ozaslan, M., Khailany, R. A., Latif, S., Junejo, Y., Saeed, M., . . . Kanabe, B. O. (2019). Synthesis, Characterization and Applications of a Novel Platinum-Based Nanoparticles: Catalytic, Antibacterial and Cytotoxic Studies. Journal of Inorganic and Organometallic Polymers and Materials. https://doi.org/10.1007/s10904-019-01387-7
- Safdar, M., Ozaslan, M., Khailany, R. A., Latif, S., Junejo, Y., Saeed, M., . . . Kanabe, B. O. (2020). Synthesis, characterization and applications of a novel platinum-based nanoparticles: catalytic, antibacterial and cytotoxic studies. Journal of Inorganic and Organometallic Polymers and Materials, 30(7), 2430-2439.
- Safdar, M., Qumar, G. M., Saravanan, M., Khailany, R. A., Ozaslan, M., Gondal, M. A., . . . Junejo, Y. J. J. o. C. S. (2019). Synthesis and characterization of Cefditoren capped silver nanoparticles and their antimicrobial and catalytic degradation of Ibuprofen. Journal of Cluster Science, 30(6), 1663-1671.
- Salem, A. K., Searson, P. C., & Leong, K. W. (2003). Multifunctional nanorods for gene delivery. Nature materials, 2(10), 668-671.
- Smith, D. M., Simon, J. K., & Baker, J. R., Jr. (2013). Applications of nanotechnology for immunology. Nat Rev Immunol, 13(8), 592-605. https://doi.org/10.1038/nri3488
- Sra, A. K., & Schaak, R. E. (2004). Synthesis of atomically ordered AuCu and AuCu3 nanocrystals from bimetallic nanoparticle precursors. Journal of the American Chemical Society, 126(21), 6667-6672.
- Surapaneni, S. K., Bashir, S., & Tikoo, K. (2018). Gold nanoparticles-induced cytotoxicity in triple negative breast cancer involves different epigenetic alterations depending upon the surface charge. Sci Rep, 8(1), 12295. https://doi.org/10.1038/s41598-018-30541-3
- Uzma, M., Sunayana, N., Raghavendra, V. B., Madhu, C. S., Shanmuganathan, R., & Brindhadevi, K. (2020). Biogenic synthesis of gold nanoparticles using Commiphora wightii and their cytotoxic effects on breast cancer cell line (MCF-7). Process Biochemistry, 92, 269-276.
- Wege, A. K., Schmidt, M., Ueberham, E., Ponnath, M., Ortmann, O., Brockhoff, G., & Lehmann, J. (2014). Co-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice: a novel approach to generate tumor cell specific human antibodies. MAbs, In MAbs (Vol. 6, No. 4, pp. 968-977). Taylor & Francis.
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Details
| Primary Language | English |
|---|---|
| Subjects | Engineering |
| Journal Section | Articles |
| Authors | |
| Publication Date | September 16, 2022 |
| Published in Issue | Year 2022 |
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