The Preparatıon of Gelatin Coated Sodium Alginate Hydrogels

Mehlika Pulat

Research Article

Year 2018, Issue: 4, 149 - 155, 04.12.2018

Mehlika Pulat

Abstract

References

Bigi A., Cojazzi G., Panzavolta S., Rubini K., Roveri N. (2001). Mechanical and ther¬mal properties of gelatin films at different degrees of glutaraldehyde crosslinking. Biomat. 22, 763-768. Blanco, M.D., Bernardo, M.V., Teijon, C., Sastre, R.L., and Teijon, J.M. (2003) Transdermal application of bupivacaine-loaded poly(acrylamide(A)-co-monomethyl itaconate) hydrogels. International Journal Pharmaceutics, 255:99–107. El-Sherbiny I.M., Lins R.J., Abdel-Bary E.M., Harding D.R.K.(2005). Preparation, char¬acterization, swelling and in vitro drug release behaviour of poly(N-AG-chitosan) interpolymeric pH and therm.-responsive hydrogels. Europ. Polym. J. 41, 2584-2591. Gilsenan P, Ross-Murphy S. 2001. Shear creep of gelatin gels from mammalian and piscine collagens. International Journal of Biological Macromolecules 29: 53–61. Hsiue, G.H., Guu, J.A., and Cheng, C.C. (2001) Poly (2-hydroxyethyl methacrylate) film as a drug delivery system for pilocarpine. Biomaterials, 22:1763–1769. Kunal Pal, Allan T. Paulson and Dérick Rousseau, (2013) Handbook of Biopolymers and Biodegradable Plastics, Chapter: 14 - Biopolymers in Controlled-Release Delivery Systems, Pages 329-363, Elsevier Inc. All]. Kushibiki T, Tomoshige R, Fukunaka Y, Kakemi M, Tabataa Y. (2003). In vivo release and gene expression of plasmid DNA by hydrogels of gelatin with different cationization extents. Journal of Control Release 90: 207–216. Pulat M., Asıl D. (2009). Fluconazole release through semi-ipn hydrogels based on chitosan, AA, and citraconic acid. J. Appl. Polym. Sci. 113, 2613-2619. Pulat M., Yoltay N. (2016). Smart fertilizers: preparation and characterization of gelatin-based hydrogels for controlled release of MAP and AN fertilizers, Agrochimica, 60:4, 249-261. Pulat M., Akalın G.O. (2013). Preparation and characterization of gelatin hydrogel support for immobilization of C. Rugosa lipase. Artif. Cells Nanomed. Biotechnol. 41, 145-151. Yong Lee, Kuen and David J. Mooney.(2012). Alginate: properties and biomedical applications, Progress in Polymer Science, 37(1): 106–126.

The Preparatıon of Gelatin Coated Sodium Alginate Hydrogels

Year 2018, Issue: 4, 149 - 155, 04.12.2018

Mehlika Pulat

Abstract

In
this study, a series of gelatin coated sodium
alginate (Na-Alg) hydrogels were prepared. Firstly, three types
of hydrogels in bead form were obtained
by using the classical ionic crosslinking method of Na-Alg with calcium chloride (CaCl₂). Second group was a series of Na-Alg
hydrogel beads coated with gelatin. The immersing method was used to get the
coated beads. The hydrogel samples were diversified by changing the
concentrations of gelatin and CaCl₂ solutions. The percentages of
Na-Alg solution was kept constant at 10%. Swelling tests of all hydrogel beads
were gravimetrically carried out in buffer solution at pH=7.0 and swelling
percentages were calculated. It is found
that swelling value is decreased by increasing of CaCl₂ from 5% to
30%. In general, the hydrogels prepared using 5% of crosslinker were unstable.
Coating conditions of Na-Alg hydrogel were varied by changing gelatin
concentrations from 10% to 20%. The increasing amount of gelatin in coated part
causes the decreasing in swelling values of hydrogel beads.

Keywords

Hydrogel , Sodium alginate , Gelatin , Swelling , Sequentially releasing

References

Bigi A., Cojazzi G., Panzavolta S., Rubini K., Roveri N. (2001). Mechanical and ther¬mal properties of gelatin films at different degrees of glutaraldehyde crosslinking. Biomat. 22, 763-768. Blanco, M.D., Bernardo, M.V., Teijon, C., Sastre, R.L., and Teijon, J.M. (2003) Transdermal application of bupivacaine-loaded poly(acrylamide(A)-co-monomethyl itaconate) hydrogels. International Journal Pharmaceutics, 255:99–107. El-Sherbiny I.M., Lins R.J., Abdel-Bary E.M., Harding D.R.K.(2005). Preparation, char¬acterization, swelling and in vitro drug release behaviour of poly(N-AG-chitosan) interpolymeric pH and therm.-responsive hydrogels. Europ. Polym. J. 41, 2584-2591. Gilsenan P, Ross-Murphy S. 2001. Shear creep of gelatin gels from mammalian and piscine collagens. International Journal of Biological Macromolecules 29: 53–61. Hsiue, G.H., Guu, J.A., and Cheng, C.C. (2001) Poly (2-hydroxyethyl methacrylate) film as a drug delivery system for pilocarpine. Biomaterials, 22:1763–1769. Kunal Pal, Allan T. Paulson and Dérick Rousseau, (2013) Handbook of Biopolymers and Biodegradable Plastics, Chapter: 14 - Biopolymers in Controlled-Release Delivery Systems, Pages 329-363, Elsevier Inc. All]. Kushibiki T, Tomoshige R, Fukunaka Y, Kakemi M, Tabataa Y. (2003). In vivo release and gene expression of plasmid DNA by hydrogels of gelatin with different cationization extents. Journal of Control Release 90: 207–216. Pulat M., Asıl D. (2009). Fluconazole release through semi-ipn hydrogels based on chitosan, AA, and citraconic acid. J. Appl. Polym. Sci. 113, 2613-2619. Pulat M., Yoltay N. (2016). Smart fertilizers: preparation and characterization of gelatin-based hydrogels for controlled release of MAP and AN fertilizers, Agrochimica, 60:4, 249-261. Pulat M., Akalın G.O. (2013). Preparation and characterization of gelatin hydrogel support for immobilization of C. Rugosa lipase. Artif. Cells Nanomed. Biotechnol. 41, 145-151. Yong Lee, Kuen and David J. Mooney.(2012). Alginate: properties and biomedical applications, Progress in Polymer Science, 37(1): 106–126.

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Details

Primary Language	English
Subjects	Engineering
Journal Section	Articles
Authors	Mehlika Pulat
Publication Date	December 4, 2018
Published in Issue	Year 2018 Issue: 4

Cite

APA	Pulat, M. (2018). The Preparatıon of Gelatin Coated Sodium Alginate Hydrogels. The Eurasia Proceedings of Science Technology Engineering and Mathematics(4), 149-155.