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In Vitro Evaluation of Anticancer Activity of Moringa Peregrina Seeds on Breast Cancer Cells

Year 2020, Volume: 11, 163 - 166, 31.12.2020

Shaymaa Fadhel Abbas Albaayıt

Abstract

Moringa peregrina have long been used traditionally to treat many diseases in Arabian Peninsula folklore medicine. The objective of this study was to determine the anticancer activity of Moringa peregrina seed ethanolic extract (MPSE) on the breast cancer cell. The 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay was used to determine the anticancer effect of MPSE treatment at concentrations ranging from 25 to 400 μg/ml against AU565 breast cancer cells. The statistical values were determined employing the statistical test of one-way analysis of variance. The results show that the MPSE inhibits the proliferation of AU565 breast cancer cells with IC50 values 201.7μg/ml. These findings suggest that MPSE has anti-proliferative effect on AU565 breast cancer cells can be used to treat and prevent cancer diseases, the outcomes is promising and paving the way for develop new natural drug for treatment of breast cancer disease.

Keywords

Moringa peregrina Cytotoxicity Activity AU565 cell

References

  • Adebayo, I. A., Arsad, H., & Samian, M. R. (2017). Antiproliferative effect on breast cancer (MCF7) of Moringa oleifera seed extracts. African Journal of Traditional, Complementary and Alternative Medicines, 14(2), 282-287.
  • Al Dhaberi, S. M. (2016). In vitro re Generation and Marker Assisted Evaluation of Genetic Fidelity in Endangered Tree Species Moringa peregrina (Forsk) Fiori. Species Moringa Peregrina (Forsk) Fiori" (2016). Theses. 453. http://scholarworks.uaeu.ac.ae/all_theses/453.
  • Albaayit, S. F. A., Rasedee, A., Abdullah, N., & Abba, Y. (2020). Methanolic extract of Clausena excavata promotes wound healing via antiinflammatory and anti-apoptotic activities. Asian Pacific Journal of Tropical Biomedicine, 10, 232-238.
  • Al-Bahran, R. M., Radif, H. M., & Albaayit, S.F.A. (2020). Evaluation of potent silver nanoparticles production from Agaricus bisporus against Helicobacter pylori. Pakistan Journal of Agricultural Sciences, 57, 1197-1201.
  • Albaayit, S. F. A., Rasedee, A., & Abdullah, N. (2020). Zerumbone-loaded nanostructured lipid carrier gel facilitates wound healing in rats. Revista Brasileira de Farmacognosia, 30,272-278.
  • Albaayit, S. F. A., & Maharjan, R. (2018). Immunomodulation of Zerumbone via Decreasing the Production of Reactive Oxygen Species from Immune Cells. Pakistan Journal of Biological Sciences, 9, 475-479.
  • Albaayit, S. F. A., Al-Khafaji, A. S. K., & Alnaimy, H. S. (2019). In vitro macrophage nitric oxide and interleukin-1 beta suppression by Moringa peregrina seed. Turkish Journal of Pharmaceutical Sciences, 16, 362-365.
  • Albaayit, S. F. A. & Ozaslan, M. (2019). Cytotoxic and urease inhibition potential of Moringa peregrina Seed Ethanolic Extract. International Journal of Pharmacology, 15, 151-155.
  • Albaayit, S. F. A., Abba, Y., Abdullah, R., & Abdullah, N. (2016). Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers. Drug design, Development and Therapy, 10, 1973-1986.
  • Albaayit, S. F. A., Abba, Y., Abdullah, R., & Abdullah, N. (2014). Evaluation of antioxidant activity and acute toxicity of Clausena excavata leaves extract. Evidence-Based Complementary and Alternative Medicine, Volume 2014, Article ID 975450, http://dx.doi.org/10.1155/2014/975450
  • Albaayit, S. F. A., Abba, Y., Rasedee, A., & Abdullah, N. (2015). Effect of Clausena excavata Burm. f.(Rutaceae) leaf extract on wound healing and antioxidant activity in rats. Drug design, development and therapy, 9, 3507.
  • Elsayed, E. A., Sharaf-Eldin, M. A., & Wadaan, M. (2015). In vitro evaluation of cytotoxic activities of essential oil from Moringa oleifera seeds on HeLa, HepG2, MCF-7, CACO-2 and L929 cell lines. Asian Pacific Journal of Cancer Prevention, 16(11), 4671-467.
  • Elsayed, E. A., Sharaf-Eldin, M. A., El-Enshasy, H. A., & Wadaan, M. (2016). In vitro assessment of anticancer properties of Moringa peregrina essential seed oil on different cell lines. Pakistan Journal of Zoology, 48(3).
  • Hadadi, S. A., Li, H., Rafie, R., Kaseloo, P., Witiak, S. M., & Siddiqui, R. A. (2018). Anti-oxidation properties of leaves, skin, pulp, and seeds extracts from green papaya and their anti-cancer activities in breast cancer cells. Journal of Cancer Metastasis and Treatment, 4, 25.
  • Huang, H. C., Syu, K. Y., & Lin, J. K. (2010). Chemical composition of Solanum nigrum linn extract and induction of autophagy by leaf water extract and its major flavonoids in AU565 breast cancer cells. Journal of Agricultural and Food Chemistry, 58(15), 8699-8708.
  • Koheil, M. A., Hussein, M. A., Othman, S. M., & El-Haddad, A. (2011). Anti-inflammatory and antioxidant activities of Moringa peregrina seeds. Free Radicals and Antioxidants, 1(2), 49-61.
  • Saeidnia, S., & Abdollahi, M. (2013). Antioxidants: friends or foe in prevention or treatment of cancer: the debate of the century. Toxicology and applied pharmacology, 271(1), 49-63.
  • Senthilkumar, A., Karuvantevida, N., Rastrelli, L., Kurup, S. S., & Cheruth, A. J. (2018). Traditional Uses, Pharmacological Efficacy, and Phytochemistry of Moringa peregrina (Forssk.) Fiori.—A Review. Front Pharmacology, 9, 465.
  • Vijayalakshmi, A., Kumar, P. R., Sakthi Priyadarsini, S., & Meenaxshi, C. (2013). In vitro antioxidant and anticancer activity of flavonoid fraction from the aerial parts of Cissus quadrangularis linn. against human breast carcinoma cell lines. Journal of Chemistry, 2013, 150675.

Year 2020, Volume: 11, 163 - 166, 31.12.2020

Shaymaa Fadhel Abbas Albaayıt

Abstract

References

  • Adebayo, I. A., Arsad, H., & Samian, M. R. (2017). Antiproliferative effect on breast cancer (MCF7) of Moringa oleifera seed extracts. African Journal of Traditional, Complementary and Alternative Medicines, 14(2), 282-287.
  • Al Dhaberi, S. M. (2016). In vitro re Generation and Marker Assisted Evaluation of Genetic Fidelity in Endangered Tree Species Moringa peregrina (Forsk) Fiori. Species Moringa Peregrina (Forsk) Fiori" (2016). Theses. 453. http://scholarworks.uaeu.ac.ae/all_theses/453.
  • Albaayit, S. F. A., Rasedee, A., Abdullah, N., & Abba, Y. (2020). Methanolic extract of Clausena excavata promotes wound healing via antiinflammatory and anti-apoptotic activities. Asian Pacific Journal of Tropical Biomedicine, 10, 232-238.
  • Al-Bahran, R. M., Radif, H. M., & Albaayit, S.F.A. (2020). Evaluation of potent silver nanoparticles production from Agaricus bisporus against Helicobacter pylori. Pakistan Journal of Agricultural Sciences, 57, 1197-1201.
  • Albaayit, S. F. A., Rasedee, A., & Abdullah, N. (2020). Zerumbone-loaded nanostructured lipid carrier gel facilitates wound healing in rats. Revista Brasileira de Farmacognosia, 30,272-278.
  • Albaayit, S. F. A., & Maharjan, R. (2018). Immunomodulation of Zerumbone via Decreasing the Production of Reactive Oxygen Species from Immune Cells. Pakistan Journal of Biological Sciences, 9, 475-479.
  • Albaayit, S. F. A., Al-Khafaji, A. S. K., & Alnaimy, H. S. (2019). In vitro macrophage nitric oxide and interleukin-1 beta suppression by Moringa peregrina seed. Turkish Journal of Pharmaceutical Sciences, 16, 362-365.
  • Albaayit, S. F. A. & Ozaslan, M. (2019). Cytotoxic and urease inhibition potential of Moringa peregrina Seed Ethanolic Extract. International Journal of Pharmacology, 15, 151-155.
  • Albaayit, S. F. A., Abba, Y., Abdullah, R., & Abdullah, N. (2016). Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers. Drug design, Development and Therapy, 10, 1973-1986.
  • Albaayit, S. F. A., Abba, Y., Abdullah, R., & Abdullah, N. (2014). Evaluation of antioxidant activity and acute toxicity of Clausena excavata leaves extract. Evidence-Based Complementary and Alternative Medicine, Volume 2014, Article ID 975450, http://dx.doi.org/10.1155/2014/975450
  • Albaayit, S. F. A., Abba, Y., Rasedee, A., & Abdullah, N. (2015). Effect of Clausena excavata Burm. f.(Rutaceae) leaf extract on wound healing and antioxidant activity in rats. Drug design, development and therapy, 9, 3507.
  • Elsayed, E. A., Sharaf-Eldin, M. A., & Wadaan, M. (2015). In vitro evaluation of cytotoxic activities of essential oil from Moringa oleifera seeds on HeLa, HepG2, MCF-7, CACO-2 and L929 cell lines. Asian Pacific Journal of Cancer Prevention, 16(11), 4671-467.
  • Elsayed, E. A., Sharaf-Eldin, M. A., El-Enshasy, H. A., & Wadaan, M. (2016). In vitro assessment of anticancer properties of Moringa peregrina essential seed oil on different cell lines. Pakistan Journal of Zoology, 48(3).
  • Hadadi, S. A., Li, H., Rafie, R., Kaseloo, P., Witiak, S. M., & Siddiqui, R. A. (2018). Anti-oxidation properties of leaves, skin, pulp, and seeds extracts from green papaya and their anti-cancer activities in breast cancer cells. Journal of Cancer Metastasis and Treatment, 4, 25.
  • Huang, H. C., Syu, K. Y., & Lin, J. K. (2010). Chemical composition of Solanum nigrum linn extract and induction of autophagy by leaf water extract and its major flavonoids in AU565 breast cancer cells. Journal of Agricultural and Food Chemistry, 58(15), 8699-8708.
  • Koheil, M. A., Hussein, M. A., Othman, S. M., & El-Haddad, A. (2011). Anti-inflammatory and antioxidant activities of Moringa peregrina seeds. Free Radicals and Antioxidants, 1(2), 49-61.
  • Saeidnia, S., & Abdollahi, M. (2013). Antioxidants: friends or foe in prevention or treatment of cancer: the debate of the century. Toxicology and applied pharmacology, 271(1), 49-63.
  • Senthilkumar, A., Karuvantevida, N., Rastrelli, L., Kurup, S. S., & Cheruth, A. J. (2018). Traditional Uses, Pharmacological Efficacy, and Phytochemistry of Moringa peregrina (Forssk.) Fiori.—A Review. Front Pharmacology, 9, 465.
  • Vijayalakshmi, A., Kumar, P. R., Sakthi Priyadarsini, S., & Meenaxshi, C. (2013). In vitro antioxidant and anticancer activity of flavonoid fraction from the aerial parts of Cissus quadrangularis linn. against human breast carcinoma cell lines. Journal of Chemistry, 2013, 150675.
There are 19 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Articles
Authors

Shaymaa Fadhel Abbas Albaayıt

Publication Date December 31, 2020
Published in Issue Year 2020 Volume: 11

Cite

APA Albaayıt, S. F. A. (2020). In Vitro Evaluation of Anticancer Activity of Moringa Peregrina Seeds on Breast Cancer Cells. The Eurasia Proceedings of Science Technology Engineering and Mathematics, 11, 163-166.
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