Synthesis, Biological Evaluation and Theoretical Studies of Hydrazone Derivatives

Noura Kıchou; Nabila Guechtoulı; Karima Ighilahriz; Manal Teferghennıt; Zakia Hank

doi:10.55549/epstem.1368268

Conference Paper

Synthesis, Biological Evaluation and Theoretical Studies of Hydrazone Derivatives

Year 2023, Volume: 23, 282 - 291, 30.09.2023

Noura Kıchou Nabila Guechtoulı Karima Ighilahriz Manal Teferghennıt Zakia Hank

https://doi.org/10.55549/epstem.1368268

Abstract

The aim of this work is to synthesize, characterize and evaluate the biological activity of a series of hydrazone derivatives. These compounds were characterized by elemental analysis, IR spectroscopy, mass spectrometry, UV-Vis Spectroscopy, 1HNMR spectra. In vitro, their antibacterial and antifungal activities were screened against bacterial species (Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli) and fungi (Candida sp). Amikacin was used as references for antibacterial and antifungal studies. The compounds were optimized at DFT/B3LYP/6-31G (d,p) level of theory. In silico, The Toxicity of the hydrazone derivatives were studied by ADMET(Absorption, distribution, metabolism, excretion, and toxicity) simulations using ADMET lab 2.0 server. The molecular docking studies are carried out to better comprehend the preferential mode of binding of these compounds against biomecular targets such as InhA enzyme characteristic of Mycobacterium Tuberculosis bacteria.

Keywords

Hydrazone derivative , Synthesis , Antibacterial activity , Theoretical study.

References

Abdullah Shah, M., & Hussain, H. (2022). Synthesis and characterization of novel hydrazone derivatives of is nicotinic hydrazide and their evaluation for antibacterial and cytotoxic potential. Molecules, 27, 6770-6782.
Andersson, B., Mishra,K., Forsgren,N., Ekstrom, F., & Linusson, A. (2020). Physical mechanisms governing substituent effects on arene–arene ınteractions in a protein milieu, The Journal of Physical Chemistry B, 124(30), 6529.
Angelova, V. T., Valcheva, V., Pencheva, T., Voynikov, Y., Vassilev,N., Mihaylova, R., Momekov, G., & Shivachev, B. (2017). Synthesis, antimycobacterial activity and docking study of 2-aroyl benzopyrano[4,3-c] pyrazol-4(1H)-one derivatives and related hydrazide-hydrazones, Bioorganic & Medicinal Chemistry Letters, 27(13), 2996–3002.

Year 2023, Volume: 23, 282 - 291, 30.09.2023

Noura Kıchou Nabila Guechtoulı Karima Ighilahriz Manal Teferghennıt Zakia Hank

https://doi.org/10.55549/epstem.1368268

Abstract

References

Abdullah Shah, M., & Hussain, H. (2022). Synthesis and characterization of novel hydrazone derivatives of is nicotinic hydrazide and their evaluation for antibacterial and cytotoxic potential. Molecules, 27, 6770-6782.
Andersson, B., Mishra,K., Forsgren,N., Ekstrom, F., & Linusson, A. (2020). Physical mechanisms governing substituent effects on arene–arene ınteractions in a protein milieu, The Journal of Physical Chemistry B, 124(30), 6529.
Angelova, V. T., Valcheva, V., Pencheva, T., Voynikov, Y., Vassilev,N., Mihaylova, R., Momekov, G., & Shivachev, B. (2017). Synthesis, antimycobacterial activity and docking study of 2-aroyl benzopyrano[4,3-c] pyrazol-4(1H)-one derivatives and related hydrazide-hydrazones, Bioorganic & Medicinal Chemistry Letters, 27(13), 2996–3002.

There are 3 citations in total.

Details

Primary Language	English
Subjects	Environmental and Sustainable Processes
Journal Section	Articles
Authors	Noura Kıchou Nabila Guechtoulı Karima Ighilahriz Manal Teferghennıt Zakia Hank
Early Pub Date	September 29, 2023
Publication Date	September 30, 2023
Published in Issue	Year 2023 Volume: 23

Cite

APA	Kıchou, N., Guechtoulı, N., Ighilahriz, K., … Teferghennıt, M. (2023). Synthesis, Biological Evaluation and Theoretical Studies of Hydrazone Derivatives. The Eurasia Proceedings of Science Technology Engineering and Mathematics, 23, 282-291. https://doi.org/10.55549/epstem.1368268