In this study, 4-(3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl-azomethine)-2-methoxyphenyl
benzoates were treated with 2,6-dimethylmorpholine in the presence of
formaldehyde according to the Mannich reaction to synthesize six novel
4-[1-(2,6-dimethylmorpholin-4-yl-methyl)-3-alkyl(aryl)-4,5-dihydro-triazol-5-on-4-yl-azomethine]-2-methoxyphenyl
benzoates. The structures of synthesized six novel heterocyclic compounds were
characterized by IR, 13C-NMR and 1H-NMR spectroscopic
methods. The novel 4-[1-(2,6-dimethylmorpholin-4-yl-methyl)-3-alkyl(aryl)-4,5-dihydro-triazol-5-on-4-yl-azomethine]-2-methoxyphenyl
benzoates were investigated in vitro
antioxidant properties by using reducing
power, free radical scavenging and metal chelating activity. For the
measurement of the reductive ability, Fe3+-Fe2+ transformation
was investigated in the presence of compound using by the method of Oyaizu (1986). The hydrogen atoms or electrons
donation ability of the synthesized compound was measured by DPPH. using the method of Blois (1958). The chelating effect of ferrous ions by the
compound was determined according to the method of Dinis, Madeira & Almeida (1994). BHT, BHA, EDTA and α-tocopherol
were used as reference antioxidant compounds. The new compounds were
examined in-vitro antimicrobial
properties against 6 different microorganisms (Bacillus substilis (ATCC11774), BacilluscCereus (ATCC11778),
Staphylococcus aureus (ATCC6538), Escherichia
coli (ATCC25922), Pseudomonas
aeruginosa (ATCC27853) and Klebsiella pneumonia (ATCC4352))
by the agar well method and the obtained results were evaluated.
Primary Language | English |
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Subjects | Engineering |
Journal Section | Articles |
Authors | |
Publication Date | August 19, 2018 |
Published in Issue | Year 2018Issue: 2 |