Research Article
Cytotoxic Activity Against Cancer Cells of Pistacia vera
Abstract
Pistacia vera
fruit, one of the leading products of today's sweet and snack sector, which has
been seen in the history of the kingdom, are able to support daily nutritional
needs and treatment of many diseases due to the phenolic and flavonoid content
in the literature. Especially the studies on colon cancer and breast cancer are
remarkable potential antitumoral activity of pistachio examined. The aim of
this study is to examine in more detail the P.
vera plant, in which we have previously tested the methanol-hexane extracts
of the seed and the test and obtained positive results. As well as observing
the cytotoxic activities of the plant extracts and active ingredients obtained
from different parts on the lung cancer cells. After counting A549 and HUVEC
cell lines which replicated in the medium, were added on 96 well plate. Then,
different part of plants extract and 2 major active ingredients also added.
Then MTT dye was applied and measured spectrophotometrically. P. vera extracts and active ingredients
which studied cytotoxic activity research were found to be effective in all
cell lines in general. Particularly P.
vera's remaining after the fruit parts, methanol extract which obtained
from waste containing leaf and stem parts and PVK-1 active agent showed
selective activity on normal cells and cancer cells, therefore we consider that
it has a high therapeutic index. We believe that this plant should be imparted
to sciences and health sector with further studies.
References
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Abstract
References
- Anonim. (2009). American Association for Cancer Research. “Pistachios may reduce lung cancer risk.” ScienceDaily Berridge, M. V., Herst, P. M., & Tan, A. S. (2005). Tetrazolium dyes as tools in cell biology: New insights into their cellular reduction. In Biotechnology annual review (Vol. 11, pp. 127–152). https://doi.org/10.1016/S1387-2656(05)11004-7 Bolling, B. W., Chen, C.-Y. O., McKay, D. L., & Blumberg, J. B. (2011). Tree nut phytochemicals: composition, antioxidant capacity, bioactivity, impact factors. A systematic review of almonds, Brazils, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios and walnuts. Nutrition Research Reviews, 24(02), 244–275. https://doi.org/10.1017/S095442241100014X Fakili, O. (2010). Türkiye’de Kekik Adı ile Anılan Bitkiler Konusunda Yapılan Çalışmaların Envanteri. Retrieved from http://traglor.cu.edu.tr/objects/objectFile/2x5rCuOF-3082013-55.pdf Fathalizadeh, J., Bagheri, V., Khorramdelazad, H., Kazemi Arababadi, M., Jafarzadeh, A., Mirzaei, M. R., … Hajizadeh, M. R. (2015). Induction of apoptosis by pistachio (Pistacia vera L.) hull extract and its molecular mechanisms of action in human hepatoma cell line HepG2. Cellular and Molecular Biology (Noisy-Le-Grand, France), 61(7), 128–134. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/26638894 Glei, M., Ludwig, D., Lamberty, J., Fischer, S., Lorkowski, S., & Schlörmann, W. (2017). Chemopreventive Potential of Raw and Roasted Pistachios Regarding Colon Carcinogenesis. Nutrients, 9(12), 1368. https://doi.org/10.3390/nu9121368 Halvorsen, B. L., Carlsen, M. H., Phillips, K. M., Bøhn, S. K., Holte, K., Jacobs, D. R., & Blomhoff, R. (2006). Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States. The American Journal of Clinical Nutrition, 84(1), 95–135. https://doi.org/10.1093/ajcn/84.1.95 Hosseinzadeh, H., Abolghasem, S., Tabassi, S., Moghadam, N. M., Rashedinia, M., & Mehri, S. (2012) . Antioxidant Activity of Pistacia vera Fruits, Leaves and Gum Extracts. Health Services Iranian Journal of Pharmaceutical Research, 11(3), 879–887. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813125/pdf/ijpr-11-879.pdf Jin, S., Zhang, Q. Y., Kang, X. M., Wang, J. X., & Zhao, W. H. (2010). Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway. Annals of Oncology, 21(2), 263–268. https://doi.org/10.1093/annonc/mdp499 Kalkanci, N., Bagci, C., Davutoglu, V., Yaman, A., Tarakcioglu, M., & Aksoy, M. (2007). Antepfıstığının Kan Kolesterol Seviyesi Üzerine Etkileri. Tarım ve Köyişleri Bakanlığı. Retrieved from https://arastirma.tarim.gov.tr/afistik/Belgeler/Taranan yayınlar/antepfıstığının kan kolesterol seviyesi üzerine etkileri 001.pdf Kashaninejad, M., & Tabil, L. G. (2011). Effect of microwave–chemical pre-treatment on compression characteristics of biomass grinds. Biosystems Engineering, 108(1), 36–45. https://doi.org/10.1016/J.BIOSYSTEMSENG.2010.10.008 Maskan, M., & Karataş, Ş. (1999). Storage stability of whole-split pistachio nuts (Pistachia vera L.) at various conditions. Food Chemistry, 66(2), 227–233. https://doi.org/10.1016/S0308-8146(99)00055-2 Sari, I., Baltaci, Y., Bagci, C., Davutoglu, V., Erel, O., Celik, H., … Aksoy, M. (2010). Effect of pistachio diet on lipid parameters, endothelial function, inflammation, and oxidative status: A prospective study. Nutrition, 26(4), 399–404. https://doi.org/10.1016/J.NUT.2009.05.023 Seifaddinipour, M., Farghadani, R., Namvar, F., Mohamad, J., & Abdul Kadir, H. (2018). Cytotoxic Effects and Anti-Angiogenesis Potential of Pistachio (Pistacia vera L.) Hulls against MCF-7 Human Breast Cancer Cells. Molecules, 23(1), 110. https://doi.org/10.3390/molecules23010110 Surh, Y.-J. (2003). Cancer chemoprevention with dietary phytochemicals. Nature Reviews Cancer, 3(10), 768–780. https://doi.org/10.1038/nrc1189 Tous, J., & Ferguson, L. (1996). Mediterranean Fruits. In: Progress in new crops. ASHS Press, Arlington, VA. Yahia, E. (2011). No Titleand technology of tropical and subtropical fruits. Oxford Cambrige Philadelphia New Delhi.
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Details
| Primary Language | English |
|---|---|
| Subjects | Engineering |
| Journal Section | Articles |
| Authors | |
| Publication Date | August 19, 2018 |
| Published in Issue | Year 2018 Issue: 2 |
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