Synthesis of Some Novel 3-Alkyl(Aryl)-4-[3-(2-furylcarbonyloxy)-4- methoxy-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-one Compounds

Onur Akyıldırım

Research Article

Year 2018, Issue: 2, 290 - 294, 19.08.2018

Onur Akyıldırım

Abstract

References

Ali, K. A., Ragab, E. A., Farghaly, T. A., & Abdalla, M. M. (2011). Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents. Acta Poloniae Pharmaceutica, 68(2), 237–47. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21485297 Chen, X., Shi, Y. M., Huang, C., Xia, S., Yang, L. J., & Yang, X. D. (2016). Novel dibenzo[b,d]furan–1H-1,2,4-triazole derivatives: Synthesis and antitumor activity. Anti-Cancer Agents in Medicinal Chemistry, 16(3), 377–386. http://doi.org/10.2174/1871520615666150817115913 Chidananda, N., Poojary, B., Sumangala, V., Kumari, N. S., Shetty, P., & Arulmoli, T. (2012). Facile synthesis, characterization and pharmacological activities of 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. European Journal of Medicinal Chemistry, 51, 124–136. http://doi.org/10.1016/j.ejmech.2012.02.030 Dashtian, K., Zare-Dorabei, R. (2017). Synthesis and characterization of functionalized mesoprous SBA-15 decorated with Fe3O4 nanoparticles for removal of Ce(III) ions from aqueous solution: ICP-OES detection and central composite design optimization. Journal of Colloid and Interface Science, 494 114-123. http://dx.doi.org/10.1016/j.jcis.2017.01.072 El-Serwy, W. S., Mohamed, N. A., Abbas, E. M., & Abdel-Rahman, R. F. (2013). Synthesis and anti-inflammatory properties of novel 1,2,4-triazole derivatives. Research on Chemical Intermediates, 39(6), 2543–2554. http://doi.org/10.1007/s11164-012-0781-9 Kumar, M., Kumar, A., Singh, M.K., Sahu, S.K., John, R.P. (2017). A novel benzidine based Schiff base “turn-on” fluorescent chemosensor for selective recognition of Zn2+. Sensors and Actuators B: Chemical, 241, 1218-1223. http://dx.doi.org/10.1016/j.snb.2016.10.008 Uzgören-Baran, A., Tel, B. C., Sargöl, D., Öztürk, E. I., Kazkayas, I., Okay, G., Ertan, M., Tozkoparan, B. (2012). Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: Novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance. European Journal of Medicinal Chemistry, 57, 398–406. http://doi.org/10.1016/j.ejmech.2012.07.009 Zhang, F., Wen, Q., Wang, S. F., Shahla Karim, B., Yang, Y. S., Liu, J. J., Zhang, W. M., Zhu, H. L. (2014). Design, synthesis and antibacterial activities of 5-(pyrazin-2-yl)-4H-1,2,4-triazole-3-thiol derivatives containing Schiff base formation as FabH inhibitory. Bioorganic & Medicinal Chemistry Letters, 24(1), 90–95. http://doi.org/10.1016/J.BMCL.2013.11.079 Zhang, S., Wu, X., Niu, Q., Guo, Z., Li, T., Liu, H. (2017). Highly selective and sensitive colorimetric and fluorescent chemosensor for rapid detection of Ag+, Cu2+ and Hg2+ based on a simple Schiff base. Journal of Fluorescence, 27 729-737. http://doi.org/10.1007/s10895-016-2005-y

Synthesis of Some Novel 3-Alkyl(Aryl)-4-[3-(2-furylcarbonyloxy)-4- methoxy-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-one Compounds

Year 2018, Issue: 2, 290 - 294, 19.08.2018

Onur Akyıldırım

Abstract

In this study, nine
novel
3-alkyl(aryl)-4-[3-(2-furylcarbonyloxy)-4-methoxy-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-one
(3) compunds were synthesized from a reaction of type 1 compunds with
3-(2-furylcarbonyloxy)-4-methoxybenzaldehyde (2) which is obtained from a
reaction of 3-hydroxy-4-methoxybenzaldehyde and furan-2-carbonyl chloride. The
finally part contains that synthesis of new compounds. The structures of these
novel compounds were characterized by using, IR, ¹H NMR and ¹³C
NMR spectral data.

Keywords

1.2.4-triazol, Schiff base, Synthesis

References

Ali, K. A., Ragab, E. A., Farghaly, T. A., & Abdalla, M. M. (2011). Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents. Acta Poloniae Pharmaceutica, 68(2), 237–47. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21485297 Chen, X., Shi, Y. M., Huang, C., Xia, S., Yang, L. J., & Yang, X. D. (2016). Novel dibenzo[b,d]furan–1H-1,2,4-triazole derivatives: Synthesis and antitumor activity. Anti-Cancer Agents in Medicinal Chemistry, 16(3), 377–386. http://doi.org/10.2174/1871520615666150817115913 Chidananda, N., Poojary, B., Sumangala, V., Kumari, N. S., Shetty, P., & Arulmoli, T. (2012). Facile synthesis, characterization and pharmacological activities of 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. European Journal of Medicinal Chemistry, 51, 124–136. http://doi.org/10.1016/j.ejmech.2012.02.030 Dashtian, K., Zare-Dorabei, R. (2017). Synthesis and characterization of functionalized mesoprous SBA-15 decorated with Fe3O4 nanoparticles for removal of Ce(III) ions from aqueous solution: ICP-OES detection and central composite design optimization. Journal of Colloid and Interface Science, 494 114-123. http://dx.doi.org/10.1016/j.jcis.2017.01.072 El-Serwy, W. S., Mohamed, N. A., Abbas, E. M., & Abdel-Rahman, R. F. (2013). Synthesis and anti-inflammatory properties of novel 1,2,4-triazole derivatives. Research on Chemical Intermediates, 39(6), 2543–2554. http://doi.org/10.1007/s11164-012-0781-9 Kumar, M., Kumar, A., Singh, M.K., Sahu, S.K., John, R.P. (2017). A novel benzidine based Schiff base “turn-on” fluorescent chemosensor for selective recognition of Zn2+. Sensors and Actuators B: Chemical, 241, 1218-1223. http://dx.doi.org/10.1016/j.snb.2016.10.008 Uzgören-Baran, A., Tel, B. C., Sargöl, D., Öztürk, E. I., Kazkayas, I., Okay, G., Ertan, M., Tozkoparan, B. (2012). Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: Novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance. European Journal of Medicinal Chemistry, 57, 398–406. http://doi.org/10.1016/j.ejmech.2012.07.009 Zhang, F., Wen, Q., Wang, S. F., Shahla Karim, B., Yang, Y. S., Liu, J. J., Zhang, W. M., Zhu, H. L. (2014). Design, synthesis and antibacterial activities of 5-(pyrazin-2-yl)-4H-1,2,4-triazole-3-thiol derivatives containing Schiff base formation as FabH inhibitory. Bioorganic & Medicinal Chemistry Letters, 24(1), 90–95. http://doi.org/10.1016/J.BMCL.2013.11.079 Zhang, S., Wu, X., Niu, Q., Guo, Z., Li, T., Liu, H. (2017). Highly selective and sensitive colorimetric and fluorescent chemosensor for rapid detection of Ag+, Cu2+ and Hg2+ based on a simple Schiff base. Journal of Fluorescence, 27 729-737. http://doi.org/10.1007/s10895-016-2005-y

There are 1 citations in total.

Details

Primary Language	English
Subjects	Engineering
Journal Section	Articles
Authors	Onur Akyıldırım
Publication Date	August 19, 2018
Published in Issue	Year 2018Issue: 2

Cite

APA	Akyıldırım, O. (2018). Synthesis of Some Novel 3-Alkyl(Aryl)-4-[3-(2-furylcarbonyloxy)-4- methoxy-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-one Compounds. The Eurasia Proceedings of Science Technology Engineering and Mathematics(2), 290-294.