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Year 2019, Volume: 6 , 32 - 38, 25.07.2019

Abstract

References

  • El-Sherbiny I.M., Lins R.J., Abdel-Bary E.M., Harding D.R.K.(2005). Preparation, characterization, swelling and in vitro drug release behaviour of poly(N-AG-chitosan) interpolymeric pH and therm.-responsive hydrogels. Europ. Polym. J. 41, 2584-2591. Esposito, E., Cortesi, R., Nastruzzi, C., (1996). Gelatin microspheres: Influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties”, Biomaterials, 17: 2009–2020. Akalin G.O and Pulat M. (2018). Preparation and Characterization of nanoporous Sodium Carboxymethyl Cellulose Hydrogel Beads, Journal of Nanomaterials, Volume 2018, 1-12. Hsiue, G.H., Guu, J.A., and Cheng, C.C. (2001) Poly (2-hydroxyethyl methacrylate) film as a drug delivery system for pilocarpine. Biomaterials, 22:1763–1769. Kühbeck, D., Mayr, J., Häring, M., Hofmann, M., Quignard, F., Díaz, D. D. (2015). Evaluation of the nitroaldol reaction in the presence of metal ion-crosslinked alginates’’ New Journal of Chemistry, 39(3), 2306-2315. Pulat M., Akalın G.O. (2013). Preparation and characterization of gelatin hydrogel support for immobilization of C. Rugosa lipase. Artif. Cells Nanomed. Biotechnol. 41, 145-151. Pulat M., Asıl D. (2009). Fluconazole release through semi-ipn hydrogels based on chitosan, AA, and citraconic acid. J. Appl. Polym. Sci. 113, 2613-2619. Pulat M. & Uğurlu N. (2016). Preparation and characterization of biodegradable gelatin-PAAm-based IPN hydrogels for controlled release of maleic acid to improve the solubility of phosphate fertilizers, Soft Materıals, , 14:4, 217–227. Pulat M., Yoltay N. (2016). Smart fertilizers: preparation and characterization of gelatin-based hydrogels for controlled release of MAP and AN fertilizers, Agrochimica, 60:4, 249-261. Reddy S. Giridhar and Saxena Pandit Akanksha ( 2011). Swelling Behavior of Calcium–Ions Crosslinked Bipolymeric Sodium Alginate–Lignosulphonic Acid Blends, International Journal of Polymeric Materials, 60:1123–1129. Sapana P. A., Paraag S.G., Shrivastav B and Sharma P. (2014). Ionotropic gelation: a promising cross linking technique for Hydrogels, Research and reviews: journal of pharmaceutics and nanotechnology, Volume 2, Issue 1, 1-6.

Preparation and Characterization of Na-Alginate Hydrogel Beads

Year 2019, Volume: 6 , 32 - 38, 25.07.2019

Abstract

A series of Na Alginate (Na-Alg) hydrogel beads were prepared by using
ionic cross linking method. The beads were obtained by dropping of Na-Alg
solution in chilled oil bath at -18 ºC first and then leaving the hardened
beads into the cross linker solution. CaCl2 solution was used for ionic cross
linking of Na-Alg molecules. While the concentration of Na-Alg solution was
kept constant, crosslinking time was changed from 5 to 30 minutes. In general,
longer crosslinking times negatively affect hydrogel formation. Swelling
behaviors of the hydrogels were studied by changing time, temperature and pH.
The higher crosslinker / polymer rates caused lower swelling values. It was
determined that the swelling percentages regularly decreased with increasing
the crossliking time. While the time increased from 5 to 30 minute, swelling
percentages decreased from 158 % to 33 %. Temperature changing negligibly
affects the swelling percentages. The prepared Na-Alg  hydrogels could not be commended as
temperature sensitive.

References

  • El-Sherbiny I.M., Lins R.J., Abdel-Bary E.M., Harding D.R.K.(2005). Preparation, characterization, swelling and in vitro drug release behaviour of poly(N-AG-chitosan) interpolymeric pH and therm.-responsive hydrogels. Europ. Polym. J. 41, 2584-2591. Esposito, E., Cortesi, R., Nastruzzi, C., (1996). Gelatin microspheres: Influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties”, Biomaterials, 17: 2009–2020. Akalin G.O and Pulat M. (2018). Preparation and Characterization of nanoporous Sodium Carboxymethyl Cellulose Hydrogel Beads, Journal of Nanomaterials, Volume 2018, 1-12. Hsiue, G.H., Guu, J.A., and Cheng, C.C. (2001) Poly (2-hydroxyethyl methacrylate) film as a drug delivery system for pilocarpine. Biomaterials, 22:1763–1769. Kühbeck, D., Mayr, J., Häring, M., Hofmann, M., Quignard, F., Díaz, D. D. (2015). Evaluation of the nitroaldol reaction in the presence of metal ion-crosslinked alginates’’ New Journal of Chemistry, 39(3), 2306-2315. Pulat M., Akalın G.O. (2013). Preparation and characterization of gelatin hydrogel support for immobilization of C. Rugosa lipase. Artif. Cells Nanomed. Biotechnol. 41, 145-151. Pulat M., Asıl D. (2009). Fluconazole release through semi-ipn hydrogels based on chitosan, AA, and citraconic acid. J. Appl. Polym. Sci. 113, 2613-2619. Pulat M. & Uğurlu N. (2016). Preparation and characterization of biodegradable gelatin-PAAm-based IPN hydrogels for controlled release of maleic acid to improve the solubility of phosphate fertilizers, Soft Materıals, , 14:4, 217–227. Pulat M., Yoltay N. (2016). Smart fertilizers: preparation and characterization of gelatin-based hydrogels for controlled release of MAP and AN fertilizers, Agrochimica, 60:4, 249-261. Reddy S. Giridhar and Saxena Pandit Akanksha ( 2011). Swelling Behavior of Calcium–Ions Crosslinked Bipolymeric Sodium Alginate–Lignosulphonic Acid Blends, International Journal of Polymeric Materials, 60:1123–1129. Sapana P. A., Paraag S.G., Shrivastav B and Sharma P. (2014). Ionotropic gelation: a promising cross linking technique for Hydrogels, Research and reviews: journal of pharmaceutics and nanotechnology, Volume 2, Issue 1, 1-6.
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Details

Primary Language English
Subjects Engineering
Journal Section Articles
Authors

Mehlika Pulat

Duygu Ozukaya

Publication Date July 25, 2019
Published in Issue Year 2019Volume: 6

Cite

APA Pulat, M., & Ozukaya, D. (2019). Preparation and Characterization of Na-Alginate Hydrogel Beads. The Eurasia Proceedings of Science Technology Engineering and Mathematics, 6, 32-38.