Research Article
Year 2019,
Volume: 7 , 141 - 146, 24.11.2019
Abstract
References
- Abdel Rahman.D E.,Mohamed.K O. (2014). Synthesis of novel 1,3,4-thiadiazole analogues with expected anticancer activity, Der Pharma Chemica, 6(1) ,P: 323- 335. Ansari K F., Lal. C. (2009). Synthesis and biological activity of some heterocyclic compounds containing benzimidazole and beta-lactam moiety, J. Chem. Sci., Vol. 121, No.6, 1017-1025. Azarifar.D., Shaebanzadeh.M. (2002). Synthesis and characterization of new 3, 5-dinaphthyl substituted 2-pyrazolines and study of their antimicrobial activity, Molecules, 7, 885-895. Bheru S.K., Man S. (2014). Synthesis, characterization, antibacterial, antioxidant, DNA binding and SAR study of a novel pyrazine moiety bearing 2-pyrazoline derivatives, New J. Chem., 38, 4290-4299. Fatondji.H.R.,Gbaguidi.F.,Kpoviessi.S.,Bero.J.,Hannaert.V.,QuetinLeclercq.J.,Poupaert.J.,Moudachirou.M.,Accrombessi.G.C. (2011). Synthesis, characterization and trypanocidal activity of some aromatic thiosemicarbazones and their 1,3,4-thiadiazolines derivatives, African Journal of Pure and Applied Chemistry, Vol. 5(1), p:59-64. Francis A.G., Robert M.G. (2011). Organic Chemistry, 8th edition,MeGraw-Hill Comparies,Inc, pp:880. Jumbad H. T., Mustafa S. K., Ammar H. A. (2014). Synthesis and characterization of novel Schiff bases containing pyrimidine unit, Arabian Journal of chemistry, 7, P:157-163. Manjula.P.S., Sarojini.B.K., Darshan Raj.C.G. (2015). Antibacterial and in vitro antioxidant activities of some 4 4-amino-1,2,4-triazole-5(4h)-thione derivatives, J Fundam appl Sci., 7(3), 394-407. Nitulescu.G.M., Draghici.C.,Olaru.O.T. (2013). New Potential Antitumor Pyrazole Derivatives: Synthesis and Cytotoxic Evaluation ,Int. J. Mol. Sci. , 14, 21805-21818. Noto R ., Buccheri F ., Cusmano G ., Gruttadauria M ., Werber G. (1991). Substituent effect on oxidative cyclization of aldehyde thiosemicarbazones with ferric chloride, J. Heterocyclic Chemistry, 28 , 1421. Patil.C B., Mahajan.S.K., Katti.S.A. (2009). Chalcone: A Versatile Molecule, J.Pharm.Sci, 3,11- 22. Rajin M., Devinder K.,Satbirm. (2014). Synthesis and Antimicrobial Activity of Some 1,3‐Disubstituted Indeno[1,2‐c]pyrazoles, J.Heterocyclic Chem, 51,203 . Saha, G.C., Khayer, K., Islam.M.R. (1992). Syntheses of thiocarbohydrazide, some thiocarbohydrazones and their cyclized products as probes for pharmacological studies, Indian J. Chem., 31, 547–551. Shailesh H.S., Pankaj S.P., Mitesh P., Bharat V., Jayesh P. (2014). Synthesis, Characterization and Antimicrobial Activity of Azetidin-2-one based Phenyl Sulfonyl Pyrazoline Derivatives, Global Journal of Science frontier Research, (14):Issue 1.,Version 1, 33-38. Shui-Lin Y., Ming-Yan Y., Zhao-Hui S., Li-Jing M., Cheng-Xia T., Jian-Quan W.,Hong-Ke W., Xing-Hai L. (2014). Synthesis and Antifungal Activity of 1,2,3-thiadiazole Derivatives Containing 1,3,4-thiadiazole Moiety , Letters in Drug Design & Discovery,11, 940-943. Valentiny.M., Martvon.A. (1982). Synthesis of N-glucosyl derivatives of 5-amino-1, 2, 3- thiadiazole and 5-substituted 2-amino-1, 3, 4-thiadiazole, Chem. Zvesti, 36 (1), 111-116. Xue-Ru. L., Hua W., Ze-Yu H., Zhi-Qing M., Jun-Tao F., Xing Z. (2014) . Design, Synthesis and Fungicidal Activities of Some Novel Pyrazole Derivatives , Molecules, 19 , 14036-14051. Yousif.E A., Hameed.A S., Bakir.E T. (2007). Synthesis and photochemical study of of poly(vinyl chloride)-1,3,4-oxadiazole and 1,3,4-thiadiazole, Journal of Al-Nahrain University, Vol.10(1), pp:7-12.
Year 2019,
Volume: 7 , 141 - 146, 24.11.2019
Abstract
A series of some 2-pyrazolideno-1,3,4-Thiadiazoline Compounds [10-15] was prepared under conventional and thermal conditions using an active starting material thiocarbohydrazide [1] as a good precursor. Thiocarbohydrazide [1] was firstly prepared through direct addition reaction between (80%) hydrazine hydrate and carbon disulfide in aqueous media and reflux conditions, then it will be converted to itʼs hydrazone derivative via condensation reaction with benzophenone in acidic media at room temperature to afford compounds 1-(diphenyl methylene) thiocarbohydrazone [2], and the later one was underwent catalytic intracyclization reaction to give 2-hydrazinyl-5,5-diphenyl-2,5-dihydro-1,3,4-thiadiazoline compound [3] in presence of ferric chloride as a selective catalyst . Finally compound [3] reacted with freshly prepared chalcones (using diffrent substituted benzaldehyde and two types of ketones represented by acetophenone and m-methoxy acetophenono) [4-9] via traditional method to yield the titled compound represented by 1-(5,5-diphenyl-2,5-dihydro-1,3,4-thiadiazol-2yl)-3,5-diaryl-4,5-dihydro pyrazolidine compounds [10-15]. All prepared compounds were illustrated by the available physical and spectral data represented by U.V, FT-IR, H1-NMR & C13-NMR.
References
- Abdel Rahman.D E.,Mohamed.K O. (2014). Synthesis of novel 1,3,4-thiadiazole analogues with expected anticancer activity, Der Pharma Chemica, 6(1) ,P: 323- 335. Ansari K F., Lal. C. (2009). Synthesis and biological activity of some heterocyclic compounds containing benzimidazole and beta-lactam moiety, J. Chem. Sci., Vol. 121, No.6, 1017-1025. Azarifar.D., Shaebanzadeh.M. (2002). Synthesis and characterization of new 3, 5-dinaphthyl substituted 2-pyrazolines and study of their antimicrobial activity, Molecules, 7, 885-895. Bheru S.K., Man S. (2014). Synthesis, characterization, antibacterial, antioxidant, DNA binding and SAR study of a novel pyrazine moiety bearing 2-pyrazoline derivatives, New J. Chem., 38, 4290-4299. Fatondji.H.R.,Gbaguidi.F.,Kpoviessi.S.,Bero.J.,Hannaert.V.,QuetinLeclercq.J.,Poupaert.J.,Moudachirou.M.,Accrombessi.G.C. (2011). Synthesis, characterization and trypanocidal activity of some aromatic thiosemicarbazones and their 1,3,4-thiadiazolines derivatives, African Journal of Pure and Applied Chemistry, Vol. 5(1), p:59-64. Francis A.G., Robert M.G. (2011). Organic Chemistry, 8th edition,MeGraw-Hill Comparies,Inc, pp:880. Jumbad H. T., Mustafa S. K., Ammar H. A. (2014). Synthesis and characterization of novel Schiff bases containing pyrimidine unit, Arabian Journal of chemistry, 7, P:157-163. Manjula.P.S., Sarojini.B.K., Darshan Raj.C.G. (2015). Antibacterial and in vitro antioxidant activities of some 4 4-amino-1,2,4-triazole-5(4h)-thione derivatives, J Fundam appl Sci., 7(3), 394-407. Nitulescu.G.M., Draghici.C.,Olaru.O.T. (2013). New Potential Antitumor Pyrazole Derivatives: Synthesis and Cytotoxic Evaluation ,Int. J. Mol. Sci. , 14, 21805-21818. Noto R ., Buccheri F ., Cusmano G ., Gruttadauria M ., Werber G. (1991). Substituent effect on oxidative cyclization of aldehyde thiosemicarbazones with ferric chloride, J. Heterocyclic Chemistry, 28 , 1421. Patil.C B., Mahajan.S.K., Katti.S.A. (2009). Chalcone: A Versatile Molecule, J.Pharm.Sci, 3,11- 22. Rajin M., Devinder K.,Satbirm. (2014). Synthesis and Antimicrobial Activity of Some 1,3‐Disubstituted Indeno[1,2‐c]pyrazoles, J.Heterocyclic Chem, 51,203 . Saha, G.C., Khayer, K., Islam.M.R. (1992). Syntheses of thiocarbohydrazide, some thiocarbohydrazones and their cyclized products as probes for pharmacological studies, Indian J. Chem., 31, 547–551. Shailesh H.S., Pankaj S.P., Mitesh P., Bharat V., Jayesh P. (2014). Synthesis, Characterization and Antimicrobial Activity of Azetidin-2-one based Phenyl Sulfonyl Pyrazoline Derivatives, Global Journal of Science frontier Research, (14):Issue 1.,Version 1, 33-38. Shui-Lin Y., Ming-Yan Y., Zhao-Hui S., Li-Jing M., Cheng-Xia T., Jian-Quan W.,Hong-Ke W., Xing-Hai L. (2014). Synthesis and Antifungal Activity of 1,2,3-thiadiazole Derivatives Containing 1,3,4-thiadiazole Moiety , Letters in Drug Design & Discovery,11, 940-943. Valentiny.M., Martvon.A. (1982). Synthesis of N-glucosyl derivatives of 5-amino-1, 2, 3- thiadiazole and 5-substituted 2-amino-1, 3, 4-thiadiazole, Chem. Zvesti, 36 (1), 111-116. Xue-Ru. L., Hua W., Ze-Yu H., Zhi-Qing M., Jun-Tao F., Xing Z. (2014) . Design, Synthesis and Fungicidal Activities of Some Novel Pyrazole Derivatives , Molecules, 19 , 14036-14051. Yousif.E A., Hameed.A S., Bakir.E T. (2007). Synthesis and photochemical study of of poly(vinyl chloride)-1,3,4-oxadiazole and 1,3,4-thiadiazole, Journal of Al-Nahrain University, Vol.10(1), pp:7-12.
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Details
| Primary Language | English |
|---|---|
| Subjects | Engineering |
| Journal Section | Articles |
| Authors | |
| Publication Date | November 24, 2019 |
| Published in Issue | Year 2019Volume: 7 |
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