Research Article
Year 2019,
Volume: 8 , 35 - 41, 10.12.2019
Abstract
References
- Artuc, M., Hermes, B., Steckelings, U. M., Grützkau, A., & Henz, B. M. (1999). Mast cells and their mediators in cutaneous wound healing - Active participants or innocent bystanders? Experimental Dermatology, 8(1), 1–16. doi:10.1111/j.1600-0625.1999.tb00342.x Babaei, S., Ansarihadipour, H., Nakhaei, M., Darabi, M., Bayat, P., Sakhaei, M., … Mohammadhoseiny, A. (2017). Effect of Omegaven on mast cell concentration in diabetic wound healing. Journal of Tissue Viability, 26(2), 125–130. doi:10.1016/j.jtv.2016.12.001 El Safoury, O., Fawzy, M. M., El Maadawa, Z. M., & Mohamed, D. H. (2009). Quantitation of mast cells and collagen fibers in skin tags. Indian Journal of Dermatology, 54(4), 319–322. doi:10.4103/0019-5154.57605 Estevão, L. R. M., De Medeiros, J. P., Simões, R. S., Arantes, R. M. E., Rachid, M. A., Da Silva, R. M. G., … Evêncio-Neto, J. (2015). Mast cell concentration and skin wound contraction in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi). Acta Cirurgica Brasileira, 30(4), 289–295. doi:10.1590/S0102-865020150040000008 Falanga, V. (2005). Wound healing and its impairment in the diabetic foot. Lancet, 366(9498), 1736–1743. doi:10.1016/S0140-6736(05)67700-8 Farahpour, M. R., Hesaraki, S., Faraji, D., Zeinalpour, R., & Aghaei, M. (2017). Hydroethanolic Allium sativum extract accelerates excision wound healing: Evidence for roles of mast-cell infiltration and intracytoplasmic carbohydrate ratio. Brazilian Journal of Pharmaceutical Sciences, 53(1). doi:10.1590/s2175-97902017000115079 Farahpour, M. R., Mirzakhani, N., Doostmohammadi, J., & Ebrahimzadeh, M. (2015). Hydroethanolic Pistacia atlantica hulls extract improved wound healing process; evidence for mast cells infiltration, angiogenesis and RNA stability. International Journal of Surgery, 17, 88–98. doi:10.1016/j.ijsu.2015.03.019 Gniadecki, R., Gajkowska, B., Bartosik, J., Hansen, M., & Wulf, H. C. (1998). Variable expression of apoptotic phenotype in keratinocytes treated with ultraviolet radiation, ceramide, or suspended in semisolid methylcellulose. Acta Dermato-Venereologica, 78(4), 248–257. Hatamochi, A., Fujiwara, K., & Ueki, H. (1984). Effects of histamine on collagen synthesis by cultured fibroblasts derived from guinea pig skin. Archives of Dermatological Research, 277(1), 60–64. doi:10.1007/BF00406482 Herring, N., & Ala, M. (1980). Process for extracting oil from egg yolks. Iba, Y., Shibata, A., Kato, M., & Masukawa, T. (2004). Possible involvement of mast cells in collagen remodeling in the late phase of cutaneous wound healing in mice. International Immunopharmacology, 4(14 SPEC.ISS.), 1873–1880. doi:10.1016/j.intimp.2004.08.009 Kempuraj, D., Caraffa, A., Ronconi, G., Lessiani, G., & Conti, P. (2016). Are mast cells important in diabetes? Polish Journal of Pathology, 67(3), 199–206. doi:10.5114/pjp.2016.63770 Komi, D. E. A., Khomtchouk, K., & Santa Maria, P. L. (2019). A review of the contribution of mast cells in wound healing: involved molecular and cellular mechanisms. Clinical Reviews in Allergy and Immunology, 8–9. doi:10.1007/s12016-019-08729-w Leal, E. C., Carvalho, E., Tellechea, A., Kafanas, A., Tecilazich, F., Kearney, C., … Veves, A. (2015). Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype. American Journal of Pathology, 185(6), 1638–1648. doi:10.1016/j.ajpath.2015.02.011 Nagappan, T., Segaran, T., Wahid, M., Ramasamy, P., & Vairappan, C. (2012). efficacy of carbazole alkaloids, essential oil and Extract of Murraya koenigii in enhancing subcutaneous wound healing in rats. Molecules, 17(12), 14449–14463. doi:10.3390/molecules171214449 Nguyen, V. T., Farman, N., Palacios-Ramirez, R., Sbeih, M., Behar-Cohen, F., Aractingi, S., & Jaisser, F. (2019). Cutaneous wound healing in diabetic mice is improved by topical mineralocorticoid receptor blockade. Journal of Investigative Dermatology, 9–10. doi:10.1016/j.jid.2019.04.030 Nishikori, Y., Shiota, N., & Okunishi, H. (2014). The role of mast cells in cutaneous wound healing in streptozotocin-induced diabetic mice. Archives of Dermatological Research, 306(9), 823–835. doi:10.1007/s00403-014-1496-0 Noli, C., & Miolo, A. (2001). The mast cell in wound healing. Veterinary Dermatology, 12(6), 303–313. doi:10.1046/j.0959-4493.2001.00272.x Ozay, Y., Guzel, S., Erdogdu, I. H., Yildirim, Z., Pehlivanoglu, B., Turk, B. A., & Darcan, S. (2018). Evaluation of the wound healing properties of luteolin ointments on excision and incision wound models in diabetic and non-diabetic rats. Records of Natural Products, 12(4), 350–366. doi:10.25135/rnp.38.17.08.135 Ozay, Y., Kasim Cayci, M., Guzel-Ozay, S., Cimbiz, A., Gurlek-Olgun, E., & Sabri Ozyurt, M. (2013). Effects of Equisetum arvense ointment on diabetic wound healing in rats. Wounds : A Compendium of Clinical Research and Practice, 25(9), 234–241. Ramsey, S. D., Newton, K., Blough, D., McCulloch, D. K., Sandhu, N., Reiber, G. E., & Wagner, E. H. (1999). Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes Care, 22(3), 382–387. doi:10.2337/diacare.22.3.382 Sarandy, M. M., Miranda, L. L., Altoé, L. S., Novaes, R. D., Zanuncio, V. V., Leite, J. P. V., & Gonçalves, R. V. (2018). Strychnos pseudoquina modulates the morphological reorganization of the scar tissue of second intention cutaneous wounds in rats. PLoS ONE, 13(4), 1–15. doi:10.1371/journal.pone.0195786 Shi, M. A., & Shi, G. P. (2012). Different roles of mast cells in obesity and diabetes: Lessons from experimental animals and humans. Frontiers in Immunology, 3(JAN), 1–12. doi:10.3389/fimmu.2012.00007 Shinn, S. E., Proctor, A., & Baum, J. I. (2018). Egg yolk as means for providing essential and beneficial fatty acids. JAOCS, Journal of the American Oil Chemists’ Society, 95(1), 5–11. doi:10.1002/aocs.12008 Siracusa, R., Impellizzeri, D., Cordaro, M., Gugliandolo, E., Peritore, A. F., Di Paola, R., & Cuzzocrea, S. (2018). Topical application of adelmidrol + trans-traumatic acid enhances skin wound healing in a streptozotocin-induced diabetic mouse model. Frontiers in Pharmacology, 9(AUG), 1–22. doi:10.3389/fphar.2018.00871 Souza Neto Junior, J. de C., De Moura Estevão, L. R., Baratella-Evêncio, L., Vieira, M. G. F., Simões, R. S., Florencio-Silva, R., … Evêncio-Neto, J. (2017). Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L. Acta Cirurgica Brasileira, 32(2), 148–156. doi:10.1590/s0102-865020170207 Tellechea, A., Kafanas, A., Leal, E. C., Tecilazich, F., Kuchibhotla, S., Auster, M. E., … Veves, A. (2013). Increased skin ınflammation and blood vessel density in human and experimental diabetes. The International Journal of Lower Extremity Wounds, 12(1), 4–11. doi:10.1177/1534734612474303 Tellechea, A., Leal, E. C., Kafanas, A., Auster, M. E., Kuchibhotla, S., Ostrovsky, Y., … Veves, A. (2016). Mast cells regulate wound healing in diabetes. Diabetes, 65(7), 2006–2019. doi:10.2337/db15-0340 Toluidine Blue Staining Protocol for Mast Cells. (n.d.). Toluidine Blue Staining Protocol for Mast Cells. Retrieved 23 October 2019, from http://www.ihcworld.com/_protocols/special_stains/toluidine_blue.htm Tonnesen, M. G., Feng, X., & Clark, R. A. F. (2000). Angiogenesis in wound healing. Journal of Investigative Dermatology Symposium Proceedings, 5(1), 40–46. doi:10.1046/j.1087-0024.2000.00014.x Weller, K., Foitzik, K., Paus, R., Syska, W., & Maurer, M. (2006). Mast cells are required for normal healing of skin wounds in mice. FASEB Journal, 20(13), 1–16. doi:10.1096/fj.06-5837fje
The Effect of Egg Yolk Oil on the Mast Cell Concentration in Excisional Wound Healing of STZ-Diabetic Rats
Abstract
Diabetes mellitus (DM) is serious metabolic disease. Impaired wound healing in DM leads to significant morbidity and mortality due to various clinical and socioeconomic issues. Wound healing is a complex mechanism involving different tissues and cells. Mast cells (MC) are the first group of cells to respond to injury and contribute to three main phases of wound healing: inflammation, proliferation, and scar formation/remodeling. The aim of this study was to evaluate the effect of egg yolk oil (EYO) on MC concentration in excisional wounds of streptozotocin (STZ) diabetic rats. Female Sprague-Dawley rats were allocated in three groups (6 rats per group) as: Group 1 (non-diabetic, topically treated with 2% fusidic acid ointment), Group 2 (STZ-diabetic, topically treated with 2% fusidic acid ointment), and Group 3 (STZ-diabetic, topically treated with EYO). On third day after single intraperitoneal injection of 65 mg/kg STZ, two full-thickness skin excisional wounds were generated on the back of all rats (day 0). On day 7 and day 14, randomly selected three rats per group were sacrificed under deep anesthesia. Skin sections were stained with toluidine blue, and MC numbers were determined. Differences in these numbers among the groups were analyzed statistically. Group 2 and Group 3 had statistically higher MC concentration on day 0 compared to Group 1 (p<0.001). Group 3 had statistically lower MC concentration on day 7 compared to Group 1 and Group 2 (p<0.01). In addition, increased MC degranulation was observed in Group 3 on the same day. The results of this study suggest that EYO induces MC degranulation, which is related to wound healing process, and decreases MC concentration in the first few days of the wound healing in STZ-diabetic rats. This decrease in MC concentration in DM is likely to be enable the wound to heal earlier than some other cases.
References
- Artuc, M., Hermes, B., Steckelings, U. M., Grützkau, A., & Henz, B. M. (1999). Mast cells and their mediators in cutaneous wound healing - Active participants or innocent bystanders? Experimental Dermatology, 8(1), 1–16. doi:10.1111/j.1600-0625.1999.tb00342.x Babaei, S., Ansarihadipour, H., Nakhaei, M., Darabi, M., Bayat, P., Sakhaei, M., … Mohammadhoseiny, A. (2017). Effect of Omegaven on mast cell concentration in diabetic wound healing. Journal of Tissue Viability, 26(2), 125–130. doi:10.1016/j.jtv.2016.12.001 El Safoury, O., Fawzy, M. M., El Maadawa, Z. M., & Mohamed, D. H. (2009). Quantitation of mast cells and collagen fibers in skin tags. Indian Journal of Dermatology, 54(4), 319–322. doi:10.4103/0019-5154.57605 Estevão, L. R. M., De Medeiros, J. P., Simões, R. S., Arantes, R. M. E., Rachid, M. A., Da Silva, R. M. G., … Evêncio-Neto, J. (2015). Mast cell concentration and skin wound contraction in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi). Acta Cirurgica Brasileira, 30(4), 289–295. doi:10.1590/S0102-865020150040000008 Falanga, V. (2005). Wound healing and its impairment in the diabetic foot. Lancet, 366(9498), 1736–1743. doi:10.1016/S0140-6736(05)67700-8 Farahpour, M. R., Hesaraki, S., Faraji, D., Zeinalpour, R., & Aghaei, M. (2017). Hydroethanolic Allium sativum extract accelerates excision wound healing: Evidence for roles of mast-cell infiltration and intracytoplasmic carbohydrate ratio. Brazilian Journal of Pharmaceutical Sciences, 53(1). doi:10.1590/s2175-97902017000115079 Farahpour, M. R., Mirzakhani, N., Doostmohammadi, J., & Ebrahimzadeh, M. (2015). Hydroethanolic Pistacia atlantica hulls extract improved wound healing process; evidence for mast cells infiltration, angiogenesis and RNA stability. International Journal of Surgery, 17, 88–98. doi:10.1016/j.ijsu.2015.03.019 Gniadecki, R., Gajkowska, B., Bartosik, J., Hansen, M., & Wulf, H. C. (1998). Variable expression of apoptotic phenotype in keratinocytes treated with ultraviolet radiation, ceramide, or suspended in semisolid methylcellulose. Acta Dermato-Venereologica, 78(4), 248–257. Hatamochi, A., Fujiwara, K., & Ueki, H. (1984). Effects of histamine on collagen synthesis by cultured fibroblasts derived from guinea pig skin. Archives of Dermatological Research, 277(1), 60–64. doi:10.1007/BF00406482 Herring, N., & Ala, M. (1980). Process for extracting oil from egg yolks. Iba, Y., Shibata, A., Kato, M., & Masukawa, T. (2004). Possible involvement of mast cells in collagen remodeling in the late phase of cutaneous wound healing in mice. International Immunopharmacology, 4(14 SPEC.ISS.), 1873–1880. doi:10.1016/j.intimp.2004.08.009 Kempuraj, D., Caraffa, A., Ronconi, G., Lessiani, G., & Conti, P. (2016). Are mast cells important in diabetes? Polish Journal of Pathology, 67(3), 199–206. doi:10.5114/pjp.2016.63770 Komi, D. E. A., Khomtchouk, K., & Santa Maria, P. L. (2019). A review of the contribution of mast cells in wound healing: involved molecular and cellular mechanisms. Clinical Reviews in Allergy and Immunology, 8–9. doi:10.1007/s12016-019-08729-w Leal, E. C., Carvalho, E., Tellechea, A., Kafanas, A., Tecilazich, F., Kearney, C., … Veves, A. (2015). Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype. American Journal of Pathology, 185(6), 1638–1648. doi:10.1016/j.ajpath.2015.02.011 Nagappan, T., Segaran, T., Wahid, M., Ramasamy, P., & Vairappan, C. (2012). efficacy of carbazole alkaloids, essential oil and Extract of Murraya koenigii in enhancing subcutaneous wound healing in rats. Molecules, 17(12), 14449–14463. doi:10.3390/molecules171214449 Nguyen, V. T., Farman, N., Palacios-Ramirez, R., Sbeih, M., Behar-Cohen, F., Aractingi, S., & Jaisser, F. (2019). Cutaneous wound healing in diabetic mice is improved by topical mineralocorticoid receptor blockade. Journal of Investigative Dermatology, 9–10. doi:10.1016/j.jid.2019.04.030 Nishikori, Y., Shiota, N., & Okunishi, H. (2014). The role of mast cells in cutaneous wound healing in streptozotocin-induced diabetic mice. Archives of Dermatological Research, 306(9), 823–835. doi:10.1007/s00403-014-1496-0 Noli, C., & Miolo, A. (2001). The mast cell in wound healing. Veterinary Dermatology, 12(6), 303–313. doi:10.1046/j.0959-4493.2001.00272.x Ozay, Y., Guzel, S., Erdogdu, I. H., Yildirim, Z., Pehlivanoglu, B., Turk, B. A., & Darcan, S. (2018). Evaluation of the wound healing properties of luteolin ointments on excision and incision wound models in diabetic and non-diabetic rats. Records of Natural Products, 12(4), 350–366. doi:10.25135/rnp.38.17.08.135 Ozay, Y., Kasim Cayci, M., Guzel-Ozay, S., Cimbiz, A., Gurlek-Olgun, E., & Sabri Ozyurt, M. (2013). Effects of Equisetum arvense ointment on diabetic wound healing in rats. Wounds : A Compendium of Clinical Research and Practice, 25(9), 234–241. Ramsey, S. D., Newton, K., Blough, D., McCulloch, D. K., Sandhu, N., Reiber, G. E., & Wagner, E. H. (1999). Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes Care, 22(3), 382–387. doi:10.2337/diacare.22.3.382 Sarandy, M. M., Miranda, L. L., Altoé, L. S., Novaes, R. D., Zanuncio, V. V., Leite, J. P. V., & Gonçalves, R. V. (2018). Strychnos pseudoquina modulates the morphological reorganization of the scar tissue of second intention cutaneous wounds in rats. PLoS ONE, 13(4), 1–15. doi:10.1371/journal.pone.0195786 Shi, M. A., & Shi, G. P. (2012). Different roles of mast cells in obesity and diabetes: Lessons from experimental animals and humans. Frontiers in Immunology, 3(JAN), 1–12. doi:10.3389/fimmu.2012.00007 Shinn, S. E., Proctor, A., & Baum, J. I. (2018). Egg yolk as means for providing essential and beneficial fatty acids. JAOCS, Journal of the American Oil Chemists’ Society, 95(1), 5–11. doi:10.1002/aocs.12008 Siracusa, R., Impellizzeri, D., Cordaro, M., Gugliandolo, E., Peritore, A. F., Di Paola, R., & Cuzzocrea, S. (2018). Topical application of adelmidrol + trans-traumatic acid enhances skin wound healing in a streptozotocin-induced diabetic mouse model. Frontiers in Pharmacology, 9(AUG), 1–22. doi:10.3389/fphar.2018.00871 Souza Neto Junior, J. de C., De Moura Estevão, L. R., Baratella-Evêncio, L., Vieira, M. G. F., Simões, R. S., Florencio-Silva, R., … Evêncio-Neto, J. (2017). Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L. Acta Cirurgica Brasileira, 32(2), 148–156. doi:10.1590/s0102-865020170207 Tellechea, A., Kafanas, A., Leal, E. C., Tecilazich, F., Kuchibhotla, S., Auster, M. E., … Veves, A. (2013). Increased skin ınflammation and blood vessel density in human and experimental diabetes. The International Journal of Lower Extremity Wounds, 12(1), 4–11. doi:10.1177/1534734612474303 Tellechea, A., Leal, E. C., Kafanas, A., Auster, M. E., Kuchibhotla, S., Ostrovsky, Y., … Veves, A. (2016). Mast cells regulate wound healing in diabetes. Diabetes, 65(7), 2006–2019. doi:10.2337/db15-0340 Toluidine Blue Staining Protocol for Mast Cells. (n.d.). Toluidine Blue Staining Protocol for Mast Cells. Retrieved 23 October 2019, from http://www.ihcworld.com/_protocols/special_stains/toluidine_blue.htm Tonnesen, M. G., Feng, X., & Clark, R. A. F. (2000). Angiogenesis in wound healing. Journal of Investigative Dermatology Symposium Proceedings, 5(1), 40–46. doi:10.1046/j.1087-0024.2000.00014.x Weller, K., Foitzik, K., Paus, R., Syska, W., & Maurer, M. (2006). Mast cells are required for normal healing of skin wounds in mice. FASEB Journal, 20(13), 1–16. doi:10.1096/fj.06-5837fje
There are 1 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Engineering |
| Journal Section | Articles |
| Authors | |
| Publication Date | December 10, 2019 |
| Published in Issue | Year 2019Volume: 8 |
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.