Abstract
References
- Beddo, V. C., & Kreuter, F. (2004). A Handbook of Statistical Analyses using SPSS. Sabine Landau and Brian Everitt. Chapman & Hall/CRC, Boca Raton, Florida, 2004. ISBN 1-58488-369-3. vii+ 354 pp. $44.95 (P).--A Handbook of Statistical Analyses using Stata . Sophia Rabe-Hesketh and Brian Everitt. Chapman & Hall/CRC, Boca Raton, Florida, 2004. ISBN 1-58488-404-5. xiii+ 308 pp. $49.95 (P). Journal of Statistical Software, 11, Book review 2/3. Burtis, C. A., Ashwood, E. R., & Bruns, D. E. (2012). Tietz textbook of clinical chemistry and molecular diagnostics-e-book: Elsevier Health Sciences. Galleze, A., Raache, R., Cherif, N., Eddaïkra, A., Belhani, M., Bensenouci, A., & Touil-Boukoffa, C. (2017). Increased level of lactate dehydrogenase correlates with disease growth in Algerian children with lymphoma. Journal of Hematology and Oncology Research, 2(4), 7. Gandhi, S., Pophali, P. A., & Witzig, T. E. (2019). Elevated serum lactate in lymphoma: Not always infection. In: American Society of Clinical Oncology. Kalita, N., & Choudhury, B. (2017). A cross sectional study evaluating the association of serum calcium, serum magnesium, and body mass index in premenopausal and postmenopausal women. Int J Res Med Sci, 51953-51958. Kind, P., & King, E. (1954). Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. Journal of clinical Pathology, 7(4), 322. Kumar, K. S., & Bhaskar, P. (2012). Osteoporosis-An Emerging Disease of the 21st Century, Part 1: An Overview. Journal of family medicine and primary care, 1(1), 66. Long, G., Tang, W., Fu, X., Liu, D., Zhang, L., Hu, G., . . . Sun, W. (2019). Pre-treatment Serum Lactate Dehydrogenase Predicts Distant Metastasis and Poor Survival in Nasopharyngeal Carcinoma. Journal of Cancer, 10(16), 3657. Lu, R., Jiang, M., Chen, Z., Xu, X., Hu, H., Zhao, X., . . . Guo, L. (2013). Lactate dehydrogenase 5 expression in Non-Hodgkin lymphoma is associated with the induced hypoxia regulated protein and poor prognosis. PloS one, 8(9). Purnamasidhi, C. A. W., Suega, K., & Bakta, I. M. (2019). Association between Lactate Dehydrogenase Levels to the Response of Non-Hodgkin Lymphoma in Elderly Patients Who Treated with First-Line Chemotherapy in Sanglah General Hospital. Open Access Macedonian Journal of Medical Sciences, 7(12), 1984. Tahannejad, Z., Dayer, D., & Samie, M. (2012). The levels of serum alkaline phosphatase and lactate dehydrogenase in Hodgkin lymphoma. Iranian Journal of Blood and Cancer, 4(3), 125-128. Taher, J. H., Hummadi, Y. M. K. A.-M., AL-Bashir, N. M. T., & AL-Araji, A. S. (2016). Lactate dehydrogenase (LD), alkaline phosphatase (ALP) isoenzymatic patterns in Iraqi children with visceral leishmaniasis before and after treatment with stibogluconate. Journal of Parasitic Diseases, 40(2), 277-284. Yadav, C., Ahmad, A., D’Souza, B., Agarwal, A., Nandini, M., Prabhu, K. A., & D’Souza, V. (2016). Serum lactate dehydrogenase in non-Hodgkin’s lymphoma: A prognostic indicator. Indian Journal of Clinical Biochemistry, 31(2), 240-242. Yildirim, R., Gundogdu, M., & Erdem, F. (2009). The levels of serum C-Reactive protein, beta 2 microglobulin, ferritin, lactate dehydrogenase and some specific proteins in patients with non-Hodgkin’s lymphoma before and after treatment. The Eurasian journal of medicine, 41(3), 165. Zinzani, P. L. (2005). Lymphoma: diagnosis, staging, natural history, and treatment strategies. Paper presented at the Seminars in oncology.
Evaluation the levels of Lactate dehydrogenase (LDH), Alkaline phosphatase (ALP), Calcium and Phosphorus in Iraqi non-Hodgkin lymphoma patients treated and untreated
Abstract
Non-Hodgkin lymphoma (NHL) is a disorder caused by malignant change of lymphocytes that affect the lymph nodes or extra-node areas. Lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) play an important role in non-Hodgkin lymphoma.Our current study aims at estimating levels of lactate dehydrogenase, alkaline phosphatase, calcium and phosphorus in Iraqi non-Hodgkin lymphoma patients treated and untreated.Patients and Methods: Our study included 120 people, including 80 people with non-Hodgkin (34 females, 46 males, ages 25-70 years) were visiting the Oncology Hospital in Mosul, Iraq. And 40 uninfected people were considered as a control group, identical in age (19 females, 21 males). In addition, the patients were divided into two groups, one under treatment and the other newly diagnosed (untreated). Serum lactate dehydrogenase, alkaline phosphatase, calcium and phosphorus were measured.The results of our study showed that the average age of patients was 56.1±11.1 years, and the average age of healthy persons is 52.2±13.8 years. The results indicated that non-Hodgkin lymphoma patients have a significant increase (P<0.0001) in levels of lactate dehydrogenase (529±164.5 U/L, NHL patients versus 299.1±34.5U/L controls) and alkaline phosphatase (298±115.7 U/L NHL patients versus 98.8±39.4U/L controls) compared to healthy people. Also, the results indicated that untreated NHL patients have a significant increase (P< 0.0001) in levels of LDH (697.6±292.3 untreated NHL patients versus 317.6±92.3 treated NHL patients) and ALP (336.3±122.4 untreated NHL patients vs. 112.3±42.3 treated NHL patients) compared to treated NHL patients.While no significant difference was shown in the levels of LDH, ALP, calcium and phosphorus between the groups of treated and healthy people.It is possible to use lactate dehydrogenase and alkaline phosphatase as an indicator to diagnose and to know the severity of the disease as well as to monitor the effect of treatment for patients.
References
- Beddo, V. C., & Kreuter, F. (2004). A Handbook of Statistical Analyses using SPSS. Sabine Landau and Brian Everitt. Chapman & Hall/CRC, Boca Raton, Florida, 2004. ISBN 1-58488-369-3. vii+ 354 pp. $44.95 (P).--A Handbook of Statistical Analyses using Stata . Sophia Rabe-Hesketh and Brian Everitt. Chapman & Hall/CRC, Boca Raton, Florida, 2004. ISBN 1-58488-404-5. xiii+ 308 pp. $49.95 (P). Journal of Statistical Software, 11, Book review 2/3. Burtis, C. A., Ashwood, E. R., & Bruns, D. E. (2012). Tietz textbook of clinical chemistry and molecular diagnostics-e-book: Elsevier Health Sciences. Galleze, A., Raache, R., Cherif, N., Eddaïkra, A., Belhani, M., Bensenouci, A., & Touil-Boukoffa, C. (2017). Increased level of lactate dehydrogenase correlates with disease growth in Algerian children with lymphoma. Journal of Hematology and Oncology Research, 2(4), 7. Gandhi, S., Pophali, P. A., & Witzig, T. E. (2019). Elevated serum lactate in lymphoma: Not always infection. In: American Society of Clinical Oncology. Kalita, N., & Choudhury, B. (2017). A cross sectional study evaluating the association of serum calcium, serum magnesium, and body mass index in premenopausal and postmenopausal women. Int J Res Med Sci, 51953-51958. Kind, P., & King, E. (1954). Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. Journal of clinical Pathology, 7(4), 322. Kumar, K. S., & Bhaskar, P. (2012). Osteoporosis-An Emerging Disease of the 21st Century, Part 1: An Overview. Journal of family medicine and primary care, 1(1), 66. Long, G., Tang, W., Fu, X., Liu, D., Zhang, L., Hu, G., . . . Sun, W. (2019). Pre-treatment Serum Lactate Dehydrogenase Predicts Distant Metastasis and Poor Survival in Nasopharyngeal Carcinoma. Journal of Cancer, 10(16), 3657. Lu, R., Jiang, M., Chen, Z., Xu, X., Hu, H., Zhao, X., . . . Guo, L. (2013). Lactate dehydrogenase 5 expression in Non-Hodgkin lymphoma is associated with the induced hypoxia regulated protein and poor prognosis. PloS one, 8(9). Purnamasidhi, C. A. W., Suega, K., & Bakta, I. M. (2019). Association between Lactate Dehydrogenase Levels to the Response of Non-Hodgkin Lymphoma in Elderly Patients Who Treated with First-Line Chemotherapy in Sanglah General Hospital. Open Access Macedonian Journal of Medical Sciences, 7(12), 1984. Tahannejad, Z., Dayer, D., & Samie, M. (2012). The levels of serum alkaline phosphatase and lactate dehydrogenase in Hodgkin lymphoma. Iranian Journal of Blood and Cancer, 4(3), 125-128. Taher, J. H., Hummadi, Y. M. K. A.-M., AL-Bashir, N. M. T., & AL-Araji, A. S. (2016). Lactate dehydrogenase (LD), alkaline phosphatase (ALP) isoenzymatic patterns in Iraqi children with visceral leishmaniasis before and after treatment with stibogluconate. Journal of Parasitic Diseases, 40(2), 277-284. Yadav, C., Ahmad, A., D’Souza, B., Agarwal, A., Nandini, M., Prabhu, K. A., & D’Souza, V. (2016). Serum lactate dehydrogenase in non-Hodgkin’s lymphoma: A prognostic indicator. Indian Journal of Clinical Biochemistry, 31(2), 240-242. Yildirim, R., Gundogdu, M., & Erdem, F. (2009). The levels of serum C-Reactive protein, beta 2 microglobulin, ferritin, lactate dehydrogenase and some specific proteins in patients with non-Hodgkin’s lymphoma before and after treatment. The Eurasian journal of medicine, 41(3), 165. Zinzani, P. L. (2005). Lymphoma: diagnosis, staging, natural history, and treatment strategies. Paper presented at the Seminars in oncology.
Details
| Primary Language | English |
|---|---|
| Subjects | Engineering |
| Journal Section | Articles |
| Authors | |
| Publication Date | June 29, 2020 |
| Published in Issue | Year 2020Volume: 9 |
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