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Evaluation of Pistacia vera Sap Waste Sections and Its Potential Role on Treatment

Year 2020, Volume: 10, 12 - 16, 31.12.2020

Abstract

It is estimated that 1.3 billion waste is produced annually in the world and this amount is expected to increase to 38-67% by the end of 2025. Considering the waste production of pistachio, it is seen that around 132 165 thousand tons of waste products have been accumulated after the product processing phase due to excessive consumption and wide usage area. However, it has been reported that there are important secondary metabolites such as "masticadienonic acid", "masticadienolic acid", "tirucallol" and "pistasionic acid" in the extract content of unused waste stem parts. Masticadienonic acid has been shown in the literature to have anti-proliferative and apoptotic activity. It has been determined that masticadienolic acid component has cytotoxic activity on five different cancer cell lines (Leukemia, Breast, Prostate, Colon and CNS). Examining the studies on the Tirukallol component, it was determined that it inhibits adhesion molecules in human endothelial cells. Pistacionic acid is a newly purified and characterized compound and only anticholinesterase and antidiabetic activities have been studied. The aim of our study is to determine whether these components obtained from stem parts have any cytotoxic effect on Mcf7 cells. Within the scope of the study, the stems were obtained from pistachio processing plants and kept at room temperature, in a cool environment. In order to obtain the compounds from sap extracts, column chromatography, ion layer chromatography (TLC) and crystallization methods which are moving phase systems were used. Mcf7 cells were exposed to different concentrations of the purified components and their cytotoxic activity was evaluated using the MTT test. Mcf7 cells were exposed to different concentrations of the purified components and their cytotoxic activity was evaluated using the MTT test. The results of our study are important preliminary data in the literature and we believe that they may contribute to further studies.

References

  • Bozorgi, M., Memariani, Z., Mobli, M., Salehi Surmaghi, M. H., Shams-Ardekani, M. R., & Rahimi, R. (2013). Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): a review of their traditional uses, phytochemistry, and pharmacology. The Scientific World Journal, 2013.
  • Cevatemre, B. (2012). Fenretinid ve İndol-3-Karbinol Kombinasyonunun Meme Kanseri Hücre Soyları Üzerindeki Sitotoksik/Apoptotik Etkilerinin Araştırılması, Yüksek lisans tezi (Master Thesis).
  • Dambagı, L.Y. (2019). Antepfıstığı (Pistacia vera L.) Meyve Sap Ekstreleri ve Saf Metabolitlerinin Antidiyabetik ve Antikolinesteraz Özellikleri. Yüksek Lisans Tezi (Master Thesis).
  • Fabani, M.P., Luna, L., Baroni, M.V., Monferran, M.V., Ighani, M., Tapia, A., Wunderlin, D.A., Feresin, G.E., 2013. Pistachio (Pistacia vera var Kerman) from Argentinean cultivars. A natural product with potential to improve human health. J. Funct. Foods 5, 1347–1356.
  • FAO. (2018). World Fertilizer Trends and Outlook to 2018. Data available at. http://www.fao.org/3/a-i4324e.pdf.
  • Fernandez-Arche, A., Saenz, M. T., Arroyo, M., De la Puerta, R., & Garcia, M. D. (2010). Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex. Phytomedicine, 17(2), 146-148.
  • Giner-Larza, E. M., Máñez, S., Giner, R. M., Recio, M. C., Prieto, J. M., Cerdá-Nicolás, M., & Ríos, J. (2002). Anti-inflammatory triterpenes from Pistacia terebinthus galls. Planta Medica, 68(04), 311-315.
  • Johann, S., Sá, N. P., Lima, L. A., Cisalpino, P. S., Cota, B. B., Alves, T. M., ... & Zani, C. L. (2010). Antifungal activity of schinol and a new biphenyl compound isolated from Schinus terebinthifolius against the pathogenic fungus Paracoccidioides brasiliensis. Annals of clinical microbiology and antimicrobials, 9(1), 30.
  • Loizou, S., Paraschos, S., Mitakou, S., Chrousos, G. P., Lekakis, I., & Moutsatsou, P. (2009). Chios mastic gum extract and isolated phytosterol tirucallol exhibit anti-inflammatory activity in human aortic endothelial cells. Experimental biology and medicine, 234(5), 553-561.
  • Mannino, G., Gentile, C., & Maffei, M. E. (2019). Chemical partitioning and DNA fingerprinting of some pistachio (Pistacia vera L.) varieties of different geographical origin. Phytochemistry, 160, 40-47.
  • Mehrnejad, M. R. (2001). The current status of pistachio pests in Iran. Cahiers options méditerranéennes, 56, 315-322.
  • Sánchez-Monroy, M., Jacobo-Herrera, N. J., Zentella-Dehesa, A., Hernández-Téllez, B., & Martínez-Vázquez, M. (2017). Masticadienonic and 3α-OH masticadienoic acids induce apoptosis and inhibit cell proliferation and tumor growth in prostate cancer xenografts in vivo. Molecules, 22(9), 1479.
  • TÜİK (2019). Bitkisel Üretim İstatistikleri [Basın Bülteni]. Erişim adresi: http://www.tuik.gov.tr/PreTablo.do?alt_id=1001.
  • Vuorinen, A., Seibert, J., Papageorgiou, V. P., Rollinger, J. M., Odermatt, A., Schuster, D., & Assimopoulou, A. N. (2015). Pistacia lentiscus oleoresin: Virtual screening and identification of masticadienonic and isomasticadienonic acids as inhibitors of 11β-hydroxysteroid dehydrogenase 1. Planta medica, 81(06), 525-532.
Year 2020, Volume: 10, 12 - 16, 31.12.2020

Abstract

References

  • Bozorgi, M., Memariani, Z., Mobli, M., Salehi Surmaghi, M. H., Shams-Ardekani, M. R., & Rahimi, R. (2013). Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): a review of their traditional uses, phytochemistry, and pharmacology. The Scientific World Journal, 2013.
  • Cevatemre, B. (2012). Fenretinid ve İndol-3-Karbinol Kombinasyonunun Meme Kanseri Hücre Soyları Üzerindeki Sitotoksik/Apoptotik Etkilerinin Araştırılması, Yüksek lisans tezi (Master Thesis).
  • Dambagı, L.Y. (2019). Antepfıstığı (Pistacia vera L.) Meyve Sap Ekstreleri ve Saf Metabolitlerinin Antidiyabetik ve Antikolinesteraz Özellikleri. Yüksek Lisans Tezi (Master Thesis).
  • Fabani, M.P., Luna, L., Baroni, M.V., Monferran, M.V., Ighani, M., Tapia, A., Wunderlin, D.A., Feresin, G.E., 2013. Pistachio (Pistacia vera var Kerman) from Argentinean cultivars. A natural product with potential to improve human health. J. Funct. Foods 5, 1347–1356.
  • FAO. (2018). World Fertilizer Trends and Outlook to 2018. Data available at. http://www.fao.org/3/a-i4324e.pdf.
  • Fernandez-Arche, A., Saenz, M. T., Arroyo, M., De la Puerta, R., & Garcia, M. D. (2010). Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex. Phytomedicine, 17(2), 146-148.
  • Giner-Larza, E. M., Máñez, S., Giner, R. M., Recio, M. C., Prieto, J. M., Cerdá-Nicolás, M., & Ríos, J. (2002). Anti-inflammatory triterpenes from Pistacia terebinthus galls. Planta Medica, 68(04), 311-315.
  • Johann, S., Sá, N. P., Lima, L. A., Cisalpino, P. S., Cota, B. B., Alves, T. M., ... & Zani, C. L. (2010). Antifungal activity of schinol and a new biphenyl compound isolated from Schinus terebinthifolius against the pathogenic fungus Paracoccidioides brasiliensis. Annals of clinical microbiology and antimicrobials, 9(1), 30.
  • Loizou, S., Paraschos, S., Mitakou, S., Chrousos, G. P., Lekakis, I., & Moutsatsou, P. (2009). Chios mastic gum extract and isolated phytosterol tirucallol exhibit anti-inflammatory activity in human aortic endothelial cells. Experimental biology and medicine, 234(5), 553-561.
  • Mannino, G., Gentile, C., & Maffei, M. E. (2019). Chemical partitioning and DNA fingerprinting of some pistachio (Pistacia vera L.) varieties of different geographical origin. Phytochemistry, 160, 40-47.
  • Mehrnejad, M. R. (2001). The current status of pistachio pests in Iran. Cahiers options méditerranéennes, 56, 315-322.
  • Sánchez-Monroy, M., Jacobo-Herrera, N. J., Zentella-Dehesa, A., Hernández-Téllez, B., & Martínez-Vázquez, M. (2017). Masticadienonic and 3α-OH masticadienoic acids induce apoptosis and inhibit cell proliferation and tumor growth in prostate cancer xenografts in vivo. Molecules, 22(9), 1479.
  • TÜİK (2019). Bitkisel Üretim İstatistikleri [Basın Bülteni]. Erişim adresi: http://www.tuik.gov.tr/PreTablo.do?alt_id=1001.
  • Vuorinen, A., Seibert, J., Papageorgiou, V. P., Rollinger, J. M., Odermatt, A., Schuster, D., & Assimopoulou, A. N. (2015). Pistacia lentiscus oleoresin: Virtual screening and identification of masticadienonic and isomasticadienonic acids as inhibitors of 11β-hydroxysteroid dehydrogenase 1. Planta medica, 81(06), 525-532.
There are 14 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Articles
Authors

Hatice Emlık

Basak Sımıtcıoglu

Ahmet Cakır

Ibrahim Halil Kılıc

Isık Didem Karagoz

Publication Date December 31, 2020
Published in Issue Year 2020Volume: 10

Cite

APA Emlık, H., Sımıtcıoglu, B., Cakır, A., Kılıc, I. H., et al. (2020). Evaluation of Pistacia vera Sap Waste Sections and Its Potential Role on Treatment. The Eurasia Proceedings of Science Technology Engineering and Mathematics, 10, 12-16.