Screening Design of Experiment Applied to Dispersive Liquid-Liquid Microextraction of UV Filters from Water
Abstract
A Plackett-Burman factorial design (PBD) has been used for the optimization of dispersive liquid-liquid microextraction (DLLME) of UV filters from water. The experimental procedure included a DLLME sample preparation prior to high-performance liquid chromatography triple quadrupole mass spectrometry (HPLC-MS/MS) measurements. The variables of the DLLME process for simultaneous preconcentration of UV filters (avobenzone and octocrylene) have been studied using PBD with twelve experimental runs. Several experimental variables including the extractant type, pH value, the disperser type, extractant volume, disperser volume, vortexing/sonication, centrifugation speed, reconstitution solvent, salt content, temperature, and centrifugation time were considered in the optimization process. PBD results revealed the most important variables that affected the extraction efficiency (EF). The first three most influential variables, as showed using a Pareto graph, were in the following order: the extractant volume > the disperser type > the extraction temperature. Based on the main effects plot, it was revealed that some variables (pH value, the disperser type, extractant volume, temperature, centrifugation speed, salt content) increased over the experimental domain, while the others (the extractant type, disperser volume, vortexing/sonication, centrifugation time, reconstitution solvent) decreased
Keywords
References
- Brausch, J. M., & Rand, G. M. (2011). A review of personal care products in the aquatic environment: Environmental concentrations and toxicity. Chemosphere, 82(11), 1518–1532.
- Chisvert, A., & Salvador, A. (2018). Ultraviolet Filters in Cosmetics : Regulatory Aspects and Analytical Methods. In Analysis of Cosmetic Products (Second Edi). Elsevier B.V.
- Chisvert, A., Benedé, J. L., & Salvador, A. (2018). Current trends on the determination of organic UV filters in environmental water samples based on microextraction techniques – A review. Analytica Chimica Acta, 1034, 22–38.
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- Ramos, S., Homem, V., & Santos, L. (2019). Simultaneous determination of synthetic musks and UV-filters in water matrices by dispersive liquid-liquid microextraction followed by gas chromatography tandem mass-spectrometry. Journal of Chromatography A, 1590(2018), 47–57.
Abstract
References
- Brausch, J. M., & Rand, G. M. (2011). A review of personal care products in the aquatic environment: Environmental concentrations and toxicity. Chemosphere, 82(11), 1518–1532.
- Chisvert, A., & Salvador, A. (2018). Ultraviolet Filters in Cosmetics : Regulatory Aspects and Analytical Methods. In Analysis of Cosmetic Products (Second Edi). Elsevier B.V.
- Chisvert, A., Benedé, J. L., & Salvador, A. (2018). Current trends on the determination of organic UV filters in environmental water samples based on microextraction techniques – A review. Analytica Chimica Acta, 1034, 22–38.
- Onjia, A. (2016). Chemometric approach to the experiment optimization and data evaluation in analytical chemistry. Faculty of Technology and Metallurgy, University of Belgrade Publication, Serbia, p. 143.
- Ramos, S., Homem, V., & Santos, L. (2019). Simultaneous determination of synthetic musks and UV-filters in water matrices by dispersive liquid-liquid microextraction followed by gas chromatography tandem mass-spectrometry. Journal of Chromatography A, 1590(2018), 47–57.
Details
| Primary Language | English |
|---|---|
| Subjects | Engineering |
| Journal Section | Articles |
| Authors | |
| Publication Date | December 31, 2020 |
| Published in Issue | Year 2020Volume: 11 |
