Synthesis of Piperazine Functionalized Calix[4]Arene-1,8-Naphthalimidine Derivatives and Preparation of Antimicrobial Transparent Biofilms
Abstract
In supramolecular chemistry, calix[n]arenes, known as the “third generation” host molecules after crown ethers and cyclodextrins, are important macrocyclic compounds (Neri et al., 2016). Calix[n]arenes are macrocyclic molecules containing phenolic rings bridged by methylene groups and are known for their ability to form inclusion complexes or act as molecular scaffolds (Fateh et al., 2021; Migliore et al., 2021). In recent years, it has been proven by various studies that some calix[n]arene derivatives are suitable for bioactivity studies. In this study, three new fluorescent calix[4]arene derivatives were formed and characterized by reacting calix[4]arene with 4-bromo-1,8-naphthalanhydride and then replacing the bromine in the naphthyl groups with piperase derivatives. These synthesized fluorescent compounds were reacted with hyaluronic acid to form transparent biofilm, and FE-SEM and EDX analyses were performed to determine the surface profiles of these prepared antimicrobial transparent biofilms. Among the synthesized compounds, compound number 7 showed significant antimicrobial activity on Sarcian lutea at a dose of 0.097 mg/ml and also, this MIC value was reported as the lowest value recorded in the entire study.
Keywords
References
- Yilmaz, M. Yildirim, A., & Uysal, A. (2025). Synthesis of piperazine functionalized calix[4]arene-1,8- naphthalimidine derivatives and preparation of antimicrobial transparent biofilms. The Eurasia Proceedings of Science, Technology, Engineering and Mathematics (EPSTEM), 35, 297-301.
Details
| Primary Language | English |
|---|---|
| Subjects | Chemical Engineering Design, Chemical Reaction |
| Journal Section | Articles |
| Authors | |
| Early Pub Date | October 20, 2025 |
| Publication Date | October 29, 2025 |
| Submission Date | April 15, 2025 |
| Acceptance Date | May 26, 2025 |
| Published in Issue | Year 2025 Volume: 35 |
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