Manifestation of Ankylosing Spondylitis and Crohn`s Disease

Abstract

Regional or granulomatous ileitis is a chronicbowel disease (Crohn's disease) that covers all the layers of the intestinalwall (transmural lesions), and sometimes spreads to the mesentery, regionallymph nodes affecting both the small and large intestines, but most oftenlocalized in the terminal section of a thin guts (regional, terminal ileitis). Thesediseases can be accompanied by damage to the peripheral joints, spine, orjoints and spine. The clinical manifestations of the joint syndrome in bothprocesses are the same. The pathogenesis of the intestinal process and jointdamage has not been fully established, but it is believed that many mechanismsparticipate in it, and in particular, toxic, immune, autoimmune. In the bloodof patients, antibodies to the cells of the intestinal mucosa, lymphocytotoxinantibodies, circulating immune complexes, in which, possibly, antigeniccomponents of intestinal microbes, etc., are also present. In Crohn's disease,articular manifestations usually occur in childhood and adolescence. The developmentof peripheral arthritis in these diseases is usually not associated with thecarriage of the histocompatibility antigen B27. Ankylosing spondylitis is morecommon in men than in women (3: 1). This disease usually develops in people whohave HLA B27. Articular changes with regional ileitis occur more often inpatients with other extraintestinal manifestations of the processes - withulcers of the oral mucosa, exacerbate erythema nodosum, gangrenous pyoderma.