Cytotoxic Activity Against Cancer Cells of Pistacia vera

Abstract

Pistacia verafruit, one of the leading products of today's sweet and snack sector, which hasbeen seen in the history of the kingdom, are able to support daily nutritionalneeds and treatment of many diseases due to the phenolic and flavonoid contentin the literature. Especially the studies on colon cancer and breast cancer areremarkable potential antitumoral activity of pistachio examined. The aim ofthis study is to examine in more detail the P.vera plant, in which we have previously tested the methanol-hexane extractsof the seed and the test and obtained positive results. As well as observingthe cytotoxic activities of the plant extracts and active ingredients obtainedfrom different parts on the lung cancer cells. After counting A549 and HUVECcell lines which replicated in the medium, were added on 96 well plate. Then,different part of plants extract and 2 major active ingredients also added.Then MTT dye was applied and measured spectrophotometrically. P. vera extracts and active ingredientswhich studied cytotoxic activity research were found to be effective in allcell lines in general. Particularly P.vera's remaining after the fruit parts, methanol extract which obtainedfrom waste containing leaf and stem parts and PVK-1 active agent showedselective activity on normal cells and cancer cells, therefore we consider thatit has a high therapeutic index. We believe that this plant should be impartedto sciences and health sector with further studies.